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Titolo:
17 beta-estradiol: Effect on CA1 hippocampal synaptic plasticity
Autore:
Foy, MR;
Indirizzi:
Loyola Marymount Univ, Dept Psychol, Los Angeles, CA 90045 USA Loyola Marymount Univ Los Angeles CA USA 90045 Los Angeles, CA 90045 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 76, anno: 2001,
pagine: 239 - 252
SICI:
1074-7427(200111)76:3<239:1BEOCH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ESTROGEN REPLACEMENT THERAPY; RECEPTOR-DEPENDENT MECHANISM; DENDRITIC SPINE DENSITY; RAT HIPPOCAMPUS; ELECTROPHYSIOLOGICAL EVIDENCE; PYRAMIDAL CELLS; DEPRESSION; ESTRADIOL; NEURONS;
Keywords:
hippocampus; synaptic plasticity; estrogen; long-term potentiation; long-term depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Foy, MR Loyola Marymount Univ, Dept Psychol, 1 LMU Dr, Los Angeles, CA 90045 USA Loyola Marymount Univ 1 LMU Dr Los Angeles CA USA 90045 90045 USA
Citazione:
M.R. Foy, "17 beta-estradiol: Effect on CA1 hippocampal synaptic plasticity", NEUROBIOL L, 76(3), 2001, pp. 239-252

Abstract

An understanding of synaptic plasticity in the mammalian brain has been one of R. F. Thompson's major pursuits throughout his illustrious career. A current series of experiments of significant interest to R. F. Thompson is an examination of the interactions between sex hormones, synaptic plasticity, aging, and stress. This research is contained within a broader project whose aim is to investigate animal models that evaluate estrogen interactionswith Alzheimer's disease. This paper reviews the recent results that have led to a better understanding of how the sex hormone estrogen influences synaptic plasticity in an important structure within the mammalian brain responsible for learning and memory: the hippocampus. In this review, a number of experiments have been highlighted that investigate the molecular mechanisms that underlie estrogen's effect on two specific forms of synaptic plasticity commonly studied in neurophysiology and the behavioral neurosciences:long-term potentiation and long-term depression. (C) 2001 Academic Press

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:40:59