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Titolo:
Mechanisms shaping fast excitatory postsynaptic currents in the central nervous system
Autore:
Glavinovic, MI;
Indirizzi:
McGill Univ, Dept Anaesthesia Res, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 Res, Montreal, PQ H3G 1Y6, Canada McGill Univ, Dept Physiol, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 siol, Montreal, PQ H3G 1Y6, Canada
Titolo Testata:
NEURAL COMPUTATION
fascicolo: 1, volume: 14, anno: 2002,
pagine: 1 - 19
SICI:
0899-7667(200201)14:1<1:MSFEPC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONTE-CARLO SIMULATION; GLUTAMATE-RECEPTOR CHANNELS; CULTURED HIPPOCAMPAL-NEURONS; CEREBELLAR PURKINJE-CELLS; AMPA KAINATE RECEPTORS; TIME-COURSE; SYNAPTIC CURRENTS; PYRAMIDAL CELLS; COCHLEAR NUCLEUS; RAT HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Glavinovic, MI McGill Univ, Dept Anaesthesia Res, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 PQ H3G 1Y6, Canada
Citazione:
M.I. Glavinovic, "Mechanisms shaping fast excitatory postsynaptic currents in the central nervous system", NEURAL COMP, 14(1), 2002, pp. 1-19

Abstract

How different factors contribute to determine the time course of the basicelement of fast glutamate-mediated excitatory postsynaptic currents (mEPSCs) in the central nervous system has been a focus of interest of neurobiologists for some years. In spite of intensive investigations, these mechanisms are not well understood. In this review, basic hypotheses are summarized,and a new hypothesis is proposed, which holds that desensitization of AMPAreceptros plays a major role in shaping the time course of fast mEPSCs. According to the new hypothesis, desensitization shortens the time course of mEPSCs largely by reducing the buffering of glutamate molecules by AMPA receptors. The hypothesis accounts for numerous findings on fast mEPSCs and isexpected to be equally fruitful as a framework for further experimental and theoretical investigations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:57:52