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Titolo:
The startle reflex in schizophrenia research
Autore:
Meincke, U; Gouzoulis-Mayfrank, E; Sass, H;
Indirizzi:
Rhein Westfal TH Aachen, Klin Psychiat & Psychotherapie, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany
Titolo Testata:
NERVENARZT
fascicolo: 11, volume: 72, anno: 2001,
pagine: 844 - 852
SICI:
0028-2804(200111)72:11<844:TSRISR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
GER
Soggetto:
INFORMATION-PROCESSING DEFICITS; PHENCYCLIDINE-INDUCED DEFICITS; PREPULSE INHIBITION DEFICITS; PRONE COLLEGE-STUDENTS; ACOUSTIC STARTLE; BLINK REFLEX; HALLUCINOGENIC DRUGS; ANIMAL-MODEL; HABITUATION; PSYCHOSIS;
Keywords:
blink reflex; information processing; prepulse inhibition; schizophrenia; startle reflex;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Meincke, U Rhein Westfal TH Aachen, Klin Psychiat & Psychotherapie, Pauwelsstr 30, D-52074 Aachen, Germany Rhein Westfal TH Aachen Pauwelsstr 30 Aachen Germany D-52074 y
Citazione:
U. Meincke et al., "The startle reflex in schizophrenia research", NERVENARZT, 72(11), 2001, pp. 844-852

Abstract

Abnormalities of attention and information processing are described as important features of schizophrenia. Theoretically, they may reflect deficiencies in central mechanisms of inhibition and selection. These deficiencies are believed to lead to cognitive fragmentation in patients with schizophrenia. Findings of an impaired prepulse-inhibition (PPI) and habituation of the startle reflex in patients with schizophrenia are thought to represent preattentive, i.e., automatic attention deficits. Other paradigms with attentional instructions help to detect and to quantify deficits in controlled attentional functions. The PPI of the auditory startle blink reflex - mediated primarily by brainstem structures - is regulated by cortico-striato-pallido-pontine influences and by neurotransmitters involved in the pathogenesisof schizophrenia. An animal model of PPI provides the possibility to test neurobiological hypotheses in schizophrenia and to screen substances for their potential antipsychotic properties. Because reduction of PPI also occurs in other neuropsychiatric disorders,further studies are required to develop new paradigms of startle modification with findings of higher specificity and probable diagnostic relevance in patients with schizophrenia.

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Documento generato il 26/01/20 alle ore 00:46:04