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Titolo:
Which properties make a neuroleptic "atypical"?
Autore:
Grunder, G; Vernaleken, I; Benkert, O;
Indirizzi:
Univ Mainz, Psychiat Klin & Poliklin, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 Klin & Poliklin, D-55131 Mainz, Germany
Titolo Testata:
NERVENARZT
fascicolo: 11, volume: 72, anno: 2001,
pagine: 833 - 843
SICI:
0028-2804(200111)72:11<833:WPMAN">2.0.ZU;2-5
Fonte:
ISI
Lingua:
GER
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MIDBRAIN DOPAMINERGIC-NEURONS; 5-HT2A RECEPTOR OCCUPANCY; HALOPERIDOL PLASMA-LEVELS; ANTIPSYCHOTIC-DRUGS; NEGATIVE SYMPTOMS; SCHIZOAFFECTIVE DISORDER; SEROTONERGIC MODULATION; SCHIZOPHRENIC-PATIENTS; PREFRONTAL CORTEX;
Keywords:
"atypical" neuroleptics; dopamine; serotonin; positron; emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Grunder, G Univ Mainz, Psychiat Klin & Poliklin, Untere Zahlbacher Str 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55131 rmany
Citazione:
G. Grunder et al., "Which properties make a neuroleptic "atypical"?", NERVENARZT, 72(11), 2001, pp. 833-843

Abstract

The group of "atypical" neuroleptics is not a homogeneous class of drugs, but pharmacologically as well as clinically disparate. Furthermore, there seems to be a continuum between "conventional" and "atypical" neuroleptics. Based on preclinical findings with these drugs and their characteristics inSPECT-and PET-studies, the most common concepts of neuroleptic "atypicality" are discussed. Combined D-2-like dopamine/5-HT2-serotonin antagonism andpreferential binding to mesolimbic dopamine neurons are believed to be themain pharmacological features of "atypical" compounds. For certain substances, affinities for specific neurotransmitter receptors as well as interactions with other non-dopaminergic systems may be essential. A relatively lowaffinity for D2-like dopamine receptors and binding to dopamine autoreceptors are probably of some importance for other compounds. The diversity of possible mechanisms suggests that there is not a single, pharmacologically established concept of "atypicality". A variety of biological mechanisms characterizes a heterogeneous group of substances, which also substantially differ in their clinical properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:18:29