Catalogo Articoli (Spogli Riviste)

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Titolo:
Soluble osteopontin and vascular calcification in hemodialysis patients
Autore:
Nitta, K; Ishizuka, T; Horita, S; Hayashi, T; Ajiro, A; Uchida, K; Honda, K; Oba, T; Kawashima, A; Yumura, W; Kabaya, T; Akiba, T; Nihei, H;
Indirizzi:
Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan Minami Senju Hosp, Dialysis Unit, Tokyo, Japan Minami Senju Hosp Tokyo Japan i Senju Hosp, Dialysis Unit, Tokyo, Japan
Titolo Testata:
NEPHRON
fascicolo: 4, volume: 89, anno: 2001,
pagine: 455 - 458
SICI:
0028-2766(200112)89:4<455:SOAVCI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC PLAQUES; MESSENGER-RNA; EXPRESSION;
Keywords:
hemodialysis; vascular calcification; osteopontin; CT scan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Nitta, K Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan Tokyo Womens Med Univ 8-1 Kawada Cho Tokyo Japan 1628666 , Japan
Citazione:
K. Nitta et al., "Soluble osteopontin and vascular calcification in hemodialysis patients", NEPHRON, 89(4), 2001, pp. 455-458

Abstract

Background: Vascular calcification often occurs in patients with uremia. As osteopontin (OPN) is not only involved in the physiological but also the pathological calcification of tissues, OPN may be associated with the pathogenesis of aortic calcification in hemodialysis (HD) patients. Methods: We examined the expression of OPN in atherosclerotic aortas of HD patients. Inaddition, we performed a prospective longitudinal study by using CT scans to detect aortic calcifications and by measuring the plasma OPN concentration by ELISA in HD patients (20 men, 16 women; mean age 55.2 +/- 21.3 years)and in healthy volunteers (18 men, 17 women; mean age 54.0 +/- 13.2 years). Results: By immunohistochemical staining, OPN was abundantly localized inatherosclerotic plaques of HD patients. The macrophages surrounding the atheromatous plaques were identified as the OPN-expressing cells. We furthermore found that the concentration of soluble plasma OPN was significantly higher in HD patients as compared with the concentrations in age-matched healthy volunteers (837.3 +/- 443.2 vs. 315.1 +/- 117.4 ng/ml, p < 0.01). The OPN concentration was positively correlated with the aortic calcification index in HD patients (r = 0.749, p < 0.01). Conclusion: These data suggest that OPN, secreted by macrophages, plays a role in the calcification of atheromatous plaques in HD patients. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 19:10:03