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Titolo:
Significantly rapid relief from steroid-resistant nephrotic syndrome by LDL apheresis compared with steroid monotherapy
Autore:
Muso, E; Mune, M; Fujii, Y; Imai, E; Ueda, N; Hatta, K; Imada, A; Takemura, T; Miki, S; Kuwahara, T; Takamitsu, Y; Tsubakihara, Y;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 ovasc Med, Sakyo Ku, Kyoto 6068397, Japan Wakayama Med Coll, Wakayama 640, Japan Wakayama Med Coll Wakayama Japan 640 ayama Med Coll, Wakayama 640, Japan Nara Med Univ, Nara, Japan Nara Med Univ Nara JapanNara Med Univ, Nara, Japan Tenri Hosp, Nara, Japan Tenri Hosp Nara JapanTenri Hosp, Nara, Japan Osaka Univ, Fac Med, Osaka, Japan Osaka Univ Osaka JapanOsaka Univ, Fac Med, Osaka, Japan Kinki Univ, Sch Med, Higashiosaka, Osaka 577, Japan Kinki Univ Higashiosaka Osaka Japan 577 d, Higashiosaka, Osaka 577, Japan Osaka Saiseikai Nakatsu Hosp, Osaka, Japan Osaka Saiseikai Nakatsu Hosp Osaka Japan kai Nakatsu Hosp, Osaka, Japan Osaka Prefectural Hosp, Osaka, Japan Osaka Prefectural Hosp Osaka JapanOsaka Prefectural Hosp, Osaka, Japan Hyogo Med Univ, Hyogo, Japan Hyogo Med Univ Hyogo JapanHyogo Med Univ, Hyogo, Japan Takasago City Hosp, Hyogo, Japan Takasago City Hosp Hyogo JapanTakasago City Hosp, Hyogo, Japan
Titolo Testata:
NEPHRON
fascicolo: 4, volume: 89, anno: 2001,
pagine: 408 - 415
SICI:
0028-2766(200112)89:4<408:SRRFSN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL SEGMENTAL GLOMERULOSCLEROSIS; DENSITY-LIPOPROTEIN APHERESIS; SULFATE CELLULOSE COLUMN; GLOMERULAR-PERMEABILITY; RENAL-FUNCTION; ADSORPTION; HYPERCHOLESTEROLEMIA; PROTEINURIA; RECURRENCE; PROGNOSIS;
Keywords:
focal segmental glomerulosclerosis; LDL apheresis; liposorber; nephrotic syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Muso, E Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawaracho, Kyoto 6068397, Japan Kyoto Univ 54 Kawaracho Kyoto Japan 6068397 Kyoto 6068397, Japan
Citazione:
E. Muso et al., "Significantly rapid relief from steroid-resistant nephrotic syndrome by LDL apheresis compared with steroid monotherapy", NEPHRON, 89(4), 2001, pp. 408-415

Abstract

Rapid amelioration of hypercholesterolemia by LDL apheresis (LDL-A) was performed for long-standing nephrotic syndrome (NS) with hyperlipidemia due to focal segmental glomerulosclerosis (FGS) and the clinical data and prognosis were compared between LDL-A-treated and nontreated groups. Seventeen steroid-resistant NS patients treated with LDL-A (LDL-A group) and 10 NS patients treated with steroids only (steroid-monotherapy (SM) group) were compared. Serum cholesterol and phospholipid levels were significantly lowered only in the LDL-A group (p < 0.01, respectively). The LDL-A group showed a significant decrease of urinary protein (UP, p < 0.01) and increase of serumalbumin (p < 0.05). Average time needed to achieve a decrease of UP to less than nephrotic range (< 3.5 g/day) was significantly shorter in the LDL-Agroup than in the SM group (p < 0.01). Although this is not a prospective study, it is highly expected that a rapid improvement of hypercholesterolemia by LDL-A in steroid-resistant NS will provide more rapid relief from NS than steroid therapy alone. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:10:40