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Titolo:
Relationship between mast cells in the tubulointerstitium and prognosis ofpatients with IgA nephropathy
Autore:
Kurusu, A; Suzuki, Y; Horikoshi, S; Shirato, I; Tomino, Y;
Indirizzi:
Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ephrol,Bunkyo Ku, Tokyo 1138421, Japan
Titolo Testata:
NEPHRON
fascicolo: 4, volume: 89, anno: 2001,
pagine: 391 - 397
SICI:
0028-2766(200112)89:4<391:RBMCIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR; TRYPTASE; LUNG; ACTIVATION; DISEASE; CHYMASE; PROCOLLAGENASE; COLLAGENASE; STROMELYSIN;
Keywords:
IgA nephropathy, prognosis; mast cells; tubulointerstitial fibrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tomino, Y Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 1138421 yo 1138421, Japan
Citazione:
A. Kurusu et al., "Relationship between mast cells in the tubulointerstitium and prognosis ofpatients with IgA nephropathy", NEPHRON, 89(4), 2001, pp. 391-397

Abstract

There have been a few reports suggesting that mast cells may play an important role in the development of fibrosis and/or the degradation of extracellular matrix. We examined the relationship between the number of distribution of mast cells in tubulointerstitium and prognosis of patients with IgA nephropathy. Renal biopsy specimens were stained with mouse monoclonal antihuman mast cell tryptase antibody and then with aniline blue. Specimens from45 patients with IgA nephropathy and from 5 patients with minimal-change nephrotic syndrome were used. There was a significant correlation between the number of mast cells per unit area of the whole tubulointerstitium and the degree of tubulointerstitial fibrosis or renal function. Patients with IgA nephropathy were divided into two groups (group 1: 'minimal' and 'slight'; group 2: 'moderate' and 'advanced') according to the classification by a previously reported method. Mast cells were mainly observed in the fibroticareas in group 1. In group 2, many mast cells were detected not only in the fibrotic but also in the nonfibrotic areas. It appears that the number ofmast cells in the nonfibrotic areas may be one of the predictive factors for the prognosis of patients with IgA nephropathy. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 15:04:38