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Titolo:
Site of action of moxonidine in the rat nephron
Autore:
Greven, J; von Bronewski-Schwarzer, B;
Indirizzi:
Rhein Westfal TH Aachen, Dept Pharmacol & Toxicol, D-52057 Aachen, GermanyRhein Westfal TH Aachen Aachen Germany D-52057 , D-52057 Aachen, Germany
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 6, volume: 364, anno: 2001,
pagine: 496 - 500
SICI:
0028-1298(200112)364:6<496:SOAOMI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL PROXIMAL TUBULE; ANESTHETIZED RATS; I-1-IMIDAZOLINE RECEPTOR; BINDING-SITES; MICROPUNCTURE; LOCALIZATION; CELLS; IMIDAZOLINES; EXCRETION; AGONIST;
Keywords:
moxonidine; micropuncture; clearance; proximal tubule; loop of Henle; distal tubule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Greven, J Rhein Westfal TH Aachen, Dept Pharmacol & Toxicol, Wendlingweg 2, D-52057 Aachen, Germany Rhein Westfal TH Aachen Wendlingweg 2 Aachen Germany D-52057 ny
Citazione:
J. Greven e B. von Bronewski-Schwarzer, "Site of action of moxonidine in the rat nephron", N-S ARCH PH, 364(6), 2001, pp. 496-500

Abstract

Moxonidine is a centrally acting antihypertensive agent which has been found to exert its blood pressure lowering effect by interaction with (alpha (2)-adrenoceptors and imidazoline receptors of the I-1-type. These receptorshave also been demonstrated to be present in the rat kidney. In the present study, clearance and micropuncture techniques were applied to anaesthetized rats to localize the site of action of moxonidine within the nephron. The clearance data show that moxonidine (0.25 mg/kg i.v., followed by a continuous i.v. infusion of 0.25 mg/h) induced a marked increase in urine flow and urinary excretion of sodium, chloride and potassium. The changes in urine flow and urinary solute excretion were accompanied by an enhanced glomerular filtration rate. The micropuncture experiments revealed that moxonidinesignificantly increased glomerular filtration rate of superficial nephrons, and significantly inhibited fractional reabsorption of fluid, sodium, potassium and chloride by similar amounts (by 9.0%-9.8%) in superficial proximal tubules. Regarding fluid and sodium reabsorption, the proximal effect ofmoxonidine was continuously weakened by a compensatory increase of reabsorption in the loop of Henle and the subsequent distal nephron segments. The inhibitory effect of moxonidine on fractional proximal potassium reabsorption was completely compensated in the loop of Henle, but the drug induced a net secretion of potassium into the segments lying beyond the early distal tubule, probably as a consequence of the increased tubule fluid and sodium load delivered to them. The experiments have identified the proximal tubuleas the principal nephron site where the diuretic action of moxonidine arises. The proximal effect may be related to the increased glomerular filtration rate and to a direct inhibitory interaction of moxonidine with the proximal Na+/H+ exchanger.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:32:39