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Titolo:
Molecules, maps and synapse specificity
Autore:
Benson, DL; Colman, DR; Huntley, GW;
Indirizzi:
CUNY Mt Sinai Sch Med, Neurobiol Res Ctr, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 s Ctr, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 eurol, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Biochem, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 ochem, New York, NY 10029 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 12, volume: 2, anno: 2001,
pagine: 899 - 909
SICI:
1471-0048(200112)2:12<899:MMASS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; CENTRAL-NERVOUS-SYSTEM; CULTURED HIPPOCAMPAL-NEURONS; CONTROLLING TARGET SELECTION; RETINO-TECTAL PROJECTION; GROWTH CONE MOTILITY; CHICK OPTIC TECTUM; GENETIC-ANALYSIS; EPH RECEPTORS; FASCICLIN-II;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
161
Recensione:
Indirizzi per estratti:
Indirizzo: Benson, DL CUNY Mt Sinai Sch Med, Neurobiol Res Ctr, 1425 Madison Ave, NewYork, NY 10029 USA CUNY Mt Sinai Sch Med 1425 Madison Ave New York NY USA 10029 SA
Citazione:
D.L. Benson et al., "Molecules, maps and synapse specificity", NAT REV NEU, 2(12), 2001, pp. 899-909

Abstract

A striking feature of the mature central nervous system is the precision of the synaptic circuitry. In contemplating the mature circuitry, it is impossible to-imagine how more than 20 billion neurons in the human brain become precisely connected through trillions of synapses. Remarkably, much of the final wiring can be established in the absence of neural activity or experience; so the algorithms that allow precise connectivity must be encoded largely by the genetic programme. This programme, honed over nearly one billion years of evolution, generates networks with the flexibility to respond to a wide range of physiological challenges. There are several contemporarymodels of how synapse specificity is achieved, many of them proposed before the identification of guidance or recognition molecules. Here we review aselection of models as frameworks for defining the nature and complexity of synaptogenesis, and evaluate their validity in view of progress made in identifying the molecular underpinnings of axon guidance, targeting and synapse formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:49:01