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Titolo:
Localization and translation of mRNA in dendrites and axons
Autore:
Job, C; Eberwine, J;
Indirizzi:
Univ Penn, Med Ctr, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 12, volume: 2, anno: 2001,
pagine: 889 - 898
SICI:
1471-0048(200112)2:12<889:LATOMI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCAL PROTEIN-SYNTHESIS; ELECTRON-MICROSCOPIC EVIDENCE; SYNAPTIC ACTIVATION CAUSES; VASOPRESSIN MESSENGER-RNA; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; ACTIN-BASED PLASTICITY; SQUID GIANT-AXON; HIPPOCAMPAL-NEURONS; SELECTIVE LOCALIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Eberwine, J Univ Penn, Med Ctr, Dept Pharmacol, Philadelphia, PA 19104 USAUniv Penn Philadelphia PA USA 19104 hiladelphia, PA 19104 USA
Citazione:
C. Job e J. Eberwine, "Localization and translation of mRNA in dendrites and axons", NAT REV NEU, 2(12), 2001, pp. 889-898

Abstract

The neurons of the brain extend axons and dendrites many hundreds of micrometres away from the cell body. The first electron microscope studies of these processes revealed that many of the structures that are found in the cell body are also present in dendrites. For example, particles resembling ribosomes and membrane structures like those of the endoplasmic reticulum (two structures that are important for protein synthesis) were seen in distal regions of dendrites, near synapses. Subsequent studies focused on identifying messenger RNAs in dendrites and providing evidence of dendritic proteinsynthesis. Transfection technologies have now been used to analyse translation within dendrites in response to pharmacological stimuli. These studiesprovide us with clues to the physiological role of the dendrite not just as a signal transducer, but also as a modulator of long-term synaptic efficacy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:42:46