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Titolo:
Dendritic spines: Structure, dynamics and regulation
Autore:
Hering, H; Sheng, M;
Indirizzi:
MIT, Dept Brain & Cognit Sci, Neurosci Res Ctr, RIKEN,Ctr Learning & Memory, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 Ctr Learning & Memory, Cambridge, MA 02139 USA MIT, Dept Biol, Neurosci Res Ctr, RIKEN,Ctr Learning & Memory, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 Ctr Learning & Memory, Cambridge, MA 02139 USA MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA MIT Cambridge MA USA02139 oward Hughes Med Inst, Cambridge, MA 02139 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 12, volume: 2, anno: 2001,
pagine: 880 - 888
SICI:
1471-0048(200112)2:12<880:DSSDAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; HIPPOCAMPAL PYRAMIDAL NEURONS; POSTSYNAPTIC DENSITY PROTEINS; HEPARAN-SULFATE PROTEOGLYCAN; ACTIN-BASED PLASTICITY; RAT HIPPOCAMPUS; MORPHOLOGICAL PLASTICITY; EXCITATORY SYNAPSES; SYNAPTIC PLASTICITY; CALCIUM DYNAMICS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Sheng, M MIT, Dept Brain & Cognit Sci, Neurosci Res Ctr, RIKEN,Ctr Learning & Memory, 77 Massachusetts Ave,E18-215, Cambridge, MA 02139 USA MIT 77 Massachusetts Ave,E18-215 Cambridge MA USA 02139 02139 USA
Citazione:
H. Hering e M. Sheng, "Dendritic spines: Structure, dynamics and regulation", NAT REV NEU, 2(12), 2001, pp. 880-888

Abstract

Dendritic spines are tiny protrusions that receive excitatory synaptic input and compartmentalize postsynaptic responses. Heterogeneous in size and shape, and modifiable by activity and experience, dendritic spines have longbeen thought to provide a morphological basis for synaptic plasticity Although advanced imaging techniques have highlighted the rapid and regulated motility of spines in living neurons, the functional significance of spine plasticity remains elusive. Recent insights into the molecular mechanisms that regulate spine morphogenesis offer potential ways to manipulate dendritic spines in vivo and to explore their physiological roles in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:51:39