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Titolo:
Accessing genetic variation: Genotyping single nucleotide polymorphisms
Autore:
Syvanen, AC;
Indirizzi:
Univ Uppsala Hosp, Dept Med Sci Mol Med, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 ol Med, S-75185 Uppsala, Sweden
Titolo Testata:
NATURE REVIEWS GENETICS
fascicolo: 12, volume: 2, anno: 2001,
pagine: 930 - 942
SICI:
1471-0056(200112)2:12<930:AGVGSN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOF MASS-SPECTROMETRY; OLIGONUCLEOTIDE LIGATION ASSAY; NUCLEIC-ACID SEQUENCES; SICKLE-CELL ANEMIA; PRIMER EXTENSION; MUTATION DETECTION; MOLECULAR BEACONS; APOLIPOPROTEIN-E; POINT MUTATIONS; PADLOCK PROBES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
138
Recensione:
Indirizzi per estratti:
Indirizzo: Syvanen, AC Univ Uppsala Hosp, Dept Med Sci Mol Med, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 185 Uppsala, Sweden
Citazione:
A.C. Syvanen, "Accessing genetic variation: Genotyping single nucleotide polymorphisms", NAT REV GEN, 2(12), 2001, pp. 930-942

Abstract

Understanding the relationship between genetic variation and biological function on a genomic scale is expected to provide fundamental new insights into the biology, evolution and pathophysiology of humans and other species. The hope that single nucleotide polymorphisms (SNPs) will allow genes thatunderlie complex disease to be identified, together with progress in identifying large sets of SNPs, are the driving forces behind intense efforts toestablish the technology for large-scale analysis of SNPs. New genotyping methods that are high throughput, accurate and cheap are urgently needed for gaining full access to the abundant genetic variation of organisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:05:45