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Titolo:
GABA(B) receptor activation enhances mGIuR-mediated responses at cerebellar excitatory synapses
Autore:
Hirono, M; Yoshioka, T; Konishi, S;
Indirizzi:
Mitsubishi Kagaku Inst Life Sci, Mol Neurobiol Lab, Machida, Tokyo 1948511, Japan Mitsubishi Kagaku Inst Life Sci Machida Tokyo Japan 1948511 948511, Japan Waseda Univ, Adv Res Inst Sci & Engn, Dept Mol Neurobiol, Tokyo 1698555, Japan Waseda Univ Tokyo Japan 1698555 Dept Mol Neurobiol, Tokyo 1698555, Japan Waseda Univ, Sch Human Sci, Dept Mol Neurobiol, Tokorozawa, Saitama 3591192, Japan Waseda Univ Tokorozawa Saitama Japan 3591192 zawa, Saitama 3591192, Japan JST, CREST, Machida, Tokyo 1948511, Japan JST Machida Tokyo Japan 1948511JST, CREST, Machida, Tokyo 1948511, Japan
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 12, volume: 4, anno: 2001,
pagine: 1207 - 1216
SICI:
1097-6256(200112)4:12<1207:GRAEMR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; TERM SYNAPTIC DEPRESSION; PURKINJE-CELLS; PRESYNAPTIC INHIBITION; INWARD CURRENT; NEUROTRANSMITTER RELEASE; B RECEPTORS; A RECEPTORS; CROSS-TALK; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Konishi, S Mitsubishi Kagaku Inst Life Sci, Mol Neurobiol Lab, 11 Minamiooya, Machida, Tokyo 1948511, Japan Mitsubishi Kagaku Inst Life Sci 11 Minamiooya Machida Tokyo Japan 1948511
Citazione:
M. Hirono et al., "GABA(B) receptor activation enhances mGIuR-mediated responses at cerebellar excitatory synapses", NAT NEUROSC, 4(12), 2001, pp. 1207-1216

Abstract

Metabotropic gamma -aminobutyric acid type B (GABA(B)) and glutamate receptors (mGluRs) are postsynaptically co-expressed at cerebellar parallel fiber (PF)-Purkinje cell (PC) excitatory synapses, but their functional interactions are unclear. We found that mGluR1 agonist-induced currents and [Ca2+](i) increases in PCs were enhanced following co-activation of GABA(B) receptors. A GABA(B) antagonist and a G-protein uncoupler suppressed these effects. Low-concentration baclofen, a GABA(B) agonist, augmented mGluR1-mediated excitatory synaptic current produced by stimulating PFs. These results indicate that postsynaptic GABA(B) receptors functionally interact with mGluR1 and enhance mGluR1-mediated excitatory transmission at PF-PC synapses. The interaction between the two types of metabotropic receptors provides a likely mechanism for regulating cerebellar synaptic plasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:35:50