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Titolo:
TNF alpha contributes to the death of NGF-dependent neurons during development
Autore:
Barker, V; Middleton, G; Davey, F; Davies, AM;
Indirizzi:
Univ Edinburgh, Royal Dick Sch Vet Studies, Dept Preclin Vet Sci, Edinburgh EH9 1QH, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH9 1QH Midlothian, Scotland Univ St Andrews, Sch Biomed Sci, St Andrews KY16 9AT, Fife, Scotland Univ St Andrews St Andrews Fife Scotland KY16 9AT Y16 9AT, Fife, Scotland Rinat Neurosci Corp, Palo Alto, CA 94304 USA Rinat Neurosci Corp Palo Alto CA USA 94304 Corp, Palo Alto, CA 94304 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 12, volume: 4, anno: 2001,
pagine: 1194 - 1198
SICI:
1097-6256(200112)4:12<1194:TACTTD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; SYMPATHETIC NEURONS; CELL-DEATH; RECEPTOR GENE; EXPRESSION; RAT; ACTIVATION; SURVIVAL; INNERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, AM Univ Edinburgh, Royal Dick Sch Vet Studies, Dept Preclin Vet Sci, Summerhall Sq, Edinburgh EH9 1QH, Midlothian, Scotland Univ Edinburgh Summerhall Sq Edinburgh Midlothian Scotland EH9 1QH
Citazione:
V. Barker et al., "TNF alpha contributes to the death of NGF-dependent neurons during development", NAT NEUROSC, 4(12), 2001, pp. 1194-1198

Abstract

Many sympathetic and sensory neurons depend on a supply of nerve growth factor (NGF) from their targets during development, and neurons that fail to obtain sufficient NGF die by apoptosis. Here we show that tumor necrosis factor alpha (TNF alpha) is involved in bringing about the death of NGF-deprived neurons. Function-blocking antibodies against either TNF alpha or TNF receptor 1 (TNFR1) rescued many sympathetic and sensory neurons following NGF deprivation in vitro. Fewer sympathetic and sensory neurons died during the phase of naturally occurring neuronal death in TNF-deficient embryos, and neurons from these embryos survived in culture better than wild-type neurons. These neurons coexpress TNF alpha and TNFR1 during this stage of development, suggesting that TNFa acts by an autocrine loop.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:31:42