Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis
Autore:
Lei, BF; DeLeo, FR; Hoe, NP; Graham, MR; Mackie, SM; Cole, RL; Liu, MY; Hill, HR; Low, DE; Federle, MJ; Scott, JR; Musser, JM;
Indirizzi:
NIAID, Rocky Mt Labs, Lab Human Bacterial Pathogenesis, Hamilton, MT 59840USA NIAID Hamilton MT USA 59840 Bacterial Pathogenesis, Hamilton, MT 59840USA Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA Med, Dept Pathol, Salt Lake City, UT USA Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA Med, Dept Pediat, Salt Lake City, UT USA Univ Utah, Sch Med, Dept Med, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA ch Med, Dept Med, Salt Lake City, UT USA Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA EmoryUniv Atlanta GA USA 30322 icrobiol & Immunol, Atlanta, GA 30322 USA Mt Sinai Hosp, Dept Microbiol, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 biol, Toronto, ON M5G 1X5, Canada Univ Toronto, Toronto, ON, Canada Univ Toronto Toronto ON CanadaUniv Toronto, Toronto, ON, Canada
Titolo Testata:
NATURE MEDICINE
fascicolo: 12, volume: 7, anno: 2001,
pagine: 1298 - 1305
SICI:
1078-8956(200112)7:12<1298:EOHIAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-A STREPTOCOCCUS; COMPLEMENT RECEPTOR TYPE-3; HYALURONIC-ACID CAPSULE; FC-GAMMA-RIII; M-PROTEIN; BINDING-SITE; INTEGRIN; MAC-1; PHAGOCYTOSIS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Lei, BF NIAID, Rocky Mt Labs, Lab Human Bacterial Pathogenesis, Hamilton, MT 59840USA NIAID Hamilton MT USA 59840 l Pathogenesis, Hamilton, MT 59840USA
Citazione:
B.F. Lei et al., "Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis", NAT MED, 7(12), 2001, pp. 1298-1305

Abstract

Microbial pathogens must evade the human immune system to survive, disseminate and cause disease. By proteome analysis of the bacterium Group A Streptococcus (GAS), we identified a secreted protein with homology to the alpha-subunit of Mac-1, a leukocyte beta (2) integrin required for innate immunity to invading microbes. The GAS Mac-1-like protein (Mac) was secreted by most pathogenic strains, produced in log-phase and controlled by the covR-covS two-component gene regulatory system, which also regulates transcription of other GAS virulence factors. Patients with GAS infection had titers ofantibody specific to Mac that correlated with the course of disease, demonstrating that Mac was produced in vivo. Mac bound to CD16 (Fc gamma RIIIB) on the surface of human polymorphonuclear leukocytes and inhibited opsonophagocytosis and production of reactive oxygen species, which resulted in significantly decreased pathogen killing. Thus, by mimicking a host-cell receptor required for an innate immune response, the GAS Mac protein inhibits professional phagocyte function by a novel strategy that enhances pathogen survival, establishment of infection and dissemination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:30:40