Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Desmoplakin is essential in epidermal sheet formation
Autore:
Vasioukhin, V; Bowers, E; Bauer, C; Degenstein, L; Fuchs, E;
Indirizzi:
Univ Chicago, Howard Hughes Med Inst, Dept Mol Genet & Cell Biol, Chicago,IL 60637 USA Univ Chicago Chicago IL USA 60637 Genet & Cell Biol, Chicago,IL 60637 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 12, volume: 3, anno: 2001,
pagine: 1076 - 1085
SICI:
1465-7392(200112)3:12<1076:DIEIES>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DESMOSOMAL PLAQUE PROTEIN; INTERMEDIATE FILAMENTS; ADHERENS JUNCTIONS; EMBRYONIC HEART; CULTURED-CELLS; PLAKOGLOBIN; HEMIDESMOSOMES; ADHESION; CADHERIN; CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Vasioukhin, V Univ Chicago, Howard Hughes Med Inst, Dept Mol Genet & Cell Biol, 5841 S Maryland Ave, Chicago, IL 60637 USA Univ Chicago 5841 S Maryland Ave Chicago IL USA 60637 37 USA
Citazione:
V. Vasioukhin et al., "Desmoplakin is essential in epidermal sheet formation", NAT CELL BI, 3(12), 2001, pp. 1076-1085

Abstract

We have generated an epidermis-specific desmoplakin (DP) mouse knockout, and show that epidermal integrity requires DP; mechanical stresses to DP-null skin cause intercellular separations. The number of epidermal desmosomes in DP-null skin is similar to wild type (WT), but they lack keratin filaments, which compromise their function. DP-null keratinocytes have few desmosomes in vitro, and are unable to undergo actin reorganization and membrane sealing during epithelial sheet formation. Adherens junctions are also reduced. In vitro, DP transgene expression rescues these defects. DP is therefore required for assembly of functional desmosomes, maintaining cytoskeletal architecture and reinforcing membrane attachments essential for stable intercellular adhesion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:39:59