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Titolo:
Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1
Autore:
Ullrich, O; Diestel, A; Eyupoglu, IY; Nitsch, R;
Indirizzi:
Humboldt Univ, Fac Med Charite, Inst Anat, Dept Cell & Neurobiol, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 Neurobiol, D-10098 Berlin, Germany
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 12, volume: 3, anno: 2001,
pagine: 1035 - 1042
SICI:
1465-7392(200112)3:12<1035:ROMEOI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL SLICE CULTURES; NF-KAPPA-B; ADP-RIBOSE POLYMERASE; DNA STRAND BREAKS; GENE-EXPRESSION; CEREBRAL-ISCHEMIA; NERVOUS-SYSTEM; CELLS MIGRATE; ACTIVATION; SYNTHETASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ullrich, O Humboldt Univ, Fac Med Charite, Inst Anat, Dept Cell & Neurobiol, Schumannstr 20-21, D-10098 Berlin, Germany Humboldt Univ Schumannstr 20-21 Berlin Germany D-10098 Germany
Citazione:
O. Ullrich et al., "Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1", NAT CELL BI, 3(12), 2001, pp. 1035-1042

Abstract

Excitotoxic brain lesions initially result in the primary destruction of brain parenchyma, after which microglial cells migrate towards the sites of injury. At these sites, the cells produce large quantities of oxygen radicals and cause secondary damage that accounts for most of the loss of brain function, Here we show that this microglial migration is strongly controlledin living brain tissue by expression of the integrin CD11a, regulated by the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) through the formation of a nuclear PARP-NF-kappaB-protein complex. Downregulation of PARP or CD11a by transfection with antisense DNA abrogated microglial migration almost completely and prevented neurons from secondary damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 15:35:36