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Titolo:
Thymus medulla consisting of epithelial islets each derived from a single progenitor
Autore:
Rodewald, HR; Paul, S; Haller, C; Bluethmann, H; Blum, C;
Indirizzi:
Univ Ulm, Dept Immunol, D-89081 Ulm, Germany Univ Ulm Ulm Germany D-89081 niv Ulm, Dept Immunol, D-89081 Ulm, Germany Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland F Hoffmann La Roche & Co Ltd, Roche Genet, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4070 asel, Switzerland
Titolo Testata:
NATURE
fascicolo: 6865, volume: 414, anno: 2001,
pagine: 763 - 768
SICI:
0028-0836(200112)414:6865<763:TMCOEI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL DIFFERENTIATION; STEM-CELLS; C-KIT; MICE; EXPANSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Rodewald, HR Univ Ulm, Dept Immunol, Albert Einstein Allee 11, D-89081 Ulm, Germany Univ Ulm Albert Einstein Allee 11 Ulm Germany D-89081 ermany
Citazione:
H.R. Rodewald et al., "Thymus medulla consisting of epithelial islets each derived from a single progenitor", NATURE, 414(6865), 2001, pp. 763-768

Abstract

The thymus is organized into medullary and cortical zones that support distinct stages of T-cell development. The formation of medulla and cortex compartments is thought to occur through invagination of an endodermal epithelial sheet into an ectodermal one at the third pharyngeal pouch and cleft, respectively(1-5). Epithelial stem/progenitor cells have been proposed to beinvolved in thymus development(6,7), but evidence for their existence has been elusive. We have constructed chimaeric mice by injecting embryonic stem (ES) cells into blastocysts using ES cells and blastocysts differing in their major histocompatibility complex (MHC) type. Here we show that the MHCclass-II-positive medullary epithelium in these chimaeras is composed of cell clusters, most of which derive from either embryonic stem cell or blastocyst, but not mixed, origin. Thus, the medulla comprises individual epithelial 'islets' each arising from a single progenitor. One thymic lobe has about 300 medullary areas that originate from as few as 900 progenitors. Islet formation can be recapitulated after implantation of 'reaggregated fetal thymic organs'(8) into mice, which shows that medullary 'stem' cells retaintheir potential until at least day 16.5 in fetal development. Thus, medulla- cortex compartmentalization is established by formation of medullary islets from single progenitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:02:46