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Titolo:
AN IN-VITRO CHEMOSENSITIVITY TEST FOR SOLID HUMAN TUMORS USING COLLAGEN GEL DROPLET EMBEDDED CULTURES
Autore:
KOBAYASHI H; TANISAKA K; DOI O; KODAMA K; HIGASHIYAMA M; NAKAGAWA H; MIYAKE M; TAKI T; HARA S; YASUTOMI M; HANATANI Y; KOTAKE K; KUBOTA T;
Indirizzi:
NITTA GELATIN INC,RES LAB,2-22 FUTAMATA YAO OSAKA 581 JAPAN OSAKA MED CTR & CARDIOVASC DIS,DEPT THORAC SURG,HIGASHINARI KU OSAKA 537 JAPAN OSAKA MED CTR & CARDIOVASC DIS,DEPT NEUROSURG,HIGASHINARI KU OSAKA 537 JAPAN KITANO HOSP,TAZUKE KOFUKAI MED RES INST,DEPT THORAC SURG,KITA KU OSAKA 530 JAPAN KINKI UNIV,SCH MED,DEPT SURG 1 OSAKAYAMA OSAKA 589 JAPAN TEIKYO UNIV,SCH MED,DEPT SURG 1,ITABASHI KU TOKYO 173 JAPAN TOCHIGI CANC CTR,DEPT SURG UTSUNOMIYA TOCHIGI 320 JAPAN KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU TOKYO 160 JAPAN
Titolo Testata:
International journal of oncology
fascicolo: 3, volume: 11, anno: 1997,
pagine: 449 - 455
SICI:
1019-6439(1997)11:3<449:AICTFS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MTT END-POINT; 3-DIMENSIONAL HISTOCULTURE; COLORIMETRIC ASSAY; DRUG SENSITIVITY; NUDE-MICE; INVITRO; GROWTH; CANCER; PROLIFERATION; CHEMOTHERAPY;
Keywords:
IN VITRO CHEMOSENSITIVITY TEST; COLLAGEN GEL DROPLET EMBEDDED CULTURE; IMAGE ANALYSIS; 3-DIMENSIONAL PRIMARY CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
H. Kobayashi et al., "AN IN-VITRO CHEMOSENSITIVITY TEST FOR SOLID HUMAN TUMORS USING COLLAGEN GEL DROPLET EMBEDDED CULTURES", International journal of oncology, 11(3), 1997, pp. 449-455

Abstract

In vitro chemosensitivity testing using a collagen gel droplet embedded culture drug sensitivity test (CD-DST), was conducted with several types of solid cancer. The overall evaluable rate was 80% (443/554), including 76% for lung (n=243), 78% for breast (n=110), 87% for gastric(n=62), 83% for colorectal (n=107) cancers and 88% for 32 metastatic brain tumors. The in vitro sensitivity of breast, gastric and colorectal cancers to mitomycin C (MMC), cisplatin (CDDP), 5-fluorouracil (5-FU) and doxorubicin (DXR) was similar to the efficacy rates reported for each drug. This was also observed with lung cancer, the sensitivity of which to MMC, CDDP, vindesine (VDS) and etoposide (VP-16) was similar to the clinical efficacy. The clinical response to chemotherapy wascompared with the results of in vitro chemosensitivity testing in Il patients: the clinical correlation was 91%, with a 80% true positive and 100% true negative rate. These results suggest that the CD-DST may be clinically useful by allowing the prediction of clinical response in various solid cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 00:30:08