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Titolo:
Gene therapy for acute diseases
Autore:
Factor, P;
Indirizzi:
Evanston NW Healthcare, Evanston, IL 60201 USA Evanston NW Healthcare Evanston IL USA 60201 care, Evanston, IL 60201 USA Northwestern Univ, Sch Med, Chicago, IL 60601 USA Northwestern Univ Chicago IL USA 60601 iv, Sch Med, Chicago, IL 60601 USA
Titolo Testata:
MOLECULAR THERAPY
fascicolo: 6, volume: 4, anno: 2001,
pagine: 515 - 524
SICI:
1525-0016(200112)4:6<515:GTFAD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOVIRUS-MEDIATED TRANSFER; GLUCOSE-TRANSPORTER GENE; ADENOASSOCIATED VIRUS VECTOR; REDUCES NEOINTIMA FORMATION; KERATINOCYTE GROWTH-FACTOR; MUSCLE CELL-PROLIFERATION; EXPERIMENTAL VEIN GRAFTS; FACTOR PATHWAY INHIBITOR; NORMAL RABBIT ARTERIES; OXIDE SYNTHASE GENE;
Keywords:
gene therapy; asthma; anticoagulation; stroke; seizure myocardial infarction; acute lung injury; subarachnoid hemorrhage;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Factor, P Evanston NW Healthcare, Evanston, IL 60201 USA Evanston NW Healthcare Evanston IL USA 60201 ston, IL 60201 USA
Citazione:
P. Factor, "Gene therapy for acute diseases", MOL THER, 4(6), 2001, pp. 515-524

Abstract

The use of gene transfer systems to study cell function makes it apparent that overexpression of a transgene can restore or improve the function of aprotein and positively influence cell function in a predetermined manner for purposes of counterbalancing cellular pathophysiology. The ability of some gene transfer vehicles to produce transgene product within hours of delivery positions gene transfer as a unique pharmaceutical administration system that can quickly affect production of biologic response modifiers in a highly compartmentalized fashion. This approach can be expected to overcome many of the adverse effects and high costs of systemic delivery of recombinant pharmaceuticals. This review highlights recent advances toward development of gene therapies for acute illnesses with particular emphasis on preclinical models of disease. In this context, a growing body of data suggests that gene therapies for polygenic and non-genetic diseases such as asthma, cardiogenic and noncardiogenic pulmonary edema, stroke, subarachnoid hemorrhage, seizures, acute myocardial infarction, endovascular thrombosis, and infections may someday be options for the treatment of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:58:42