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Titolo:
GLUT2 in pancreatic and extra-pancreatic gluco-detection
Autore:
Thorens, B;
Indirizzi:
Univ Lausanne, Inst Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1005 CH-1005 Lausanne, Switzerland
Titolo Testata:
MOLECULAR MEMBRANE BIOLOGY
fascicolo: 4, volume: 18, anno: 2001,
pagine: 265 - 273
SICI:
0968-7688(200110/12)18:4<265:GIPAEG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTONOMIC NERVOUS-SYSTEM; FANCONI-BICKEL-SYNDROME; PERFUSED-RAT-LIVER; INSULIN-SECRETION; BETA-CELLS; GLUCAGON-SECRETION; GENE-EXPRESSION; SYMPATHETIC RESPONSE; HYPOTHALAMIC NEURONS; SENSITIVE NEURONS;
Keywords:
glucose transporter; glucose sensing; pancreatic islets; hypothalamus; autonomic nervous system; glucagon; insulin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Thorens, B Univ Lausanne, Inst Pharmacol & Toxicol, 27 Rue Bugnon, CH-1005Lausanne, Switzerland Univ Lausanne 27 Rue Bugnon Lausanne Switzerland CH-1005 rland
Citazione:
B. Thorens, "GLUT2 in pancreatic and extra-pancreatic gluco-detection", MOL MEMBR B, 18(4), 2001, pp. 265-273

Abstract

Detection of variations in blood glucose concentrations by pancreatic beta-cells and a subsequent appropriate secretion of insulin are key events inthe control of glucose homeostasis. Because a decreased capability to sense glycemic changes is a hallmark of type 2 diabetes, the glucose signallingpathway leading to insulin secretion in pancreatic beta -cells has been extensively studied. This signalling mechanism depends on glucose metabolism and requires the presence of specific molecules such as GLUT2, glucokinase and the K-ATP channel subunits Kir6.2 and SUR1. Other cells are also able to sense variations in glycemia or in local glucose concentrations and to modulate different physiological functions participating in the general control of glucose and energy homeostasis. These include cells forming the hepatoportal vein glucose sensor, which controls glucose storage in the liver, counterregulation, food intake and glucose utilization by peripheral tissuesand neurons in the hypothalamus and brainstem whose firing rates are modulated by local variations in glucose concentrations or, when not protected by a blood-brain barrier, directly by changes in blood glucose levels. Theseglucose-sensing neurons are involved in the control of insulin and glucagon secretion, food intake and energy expenditure. Here, recent physiologicalstudies performed with GLUT2(-/-) mice will be described, which indicate that this transporter is essential for glucose sensing by pancreatic beta -cells, by the hepatoportal sensor and by sensors, probably located centrally, which control activity of the autonomic nervous system and stimulate glucagon secretion. These studies may pave the way to a fine dissection of the molecular and cellular components of extrapancreatic glucose sensors involved in the control of glucose and energy homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:43:19