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Titolo:
Notch signaling can inhibit Xath5 function in the neural plate and developing retina
Autore:
Schneider, ML; Turner, DL; Vetter, ML;
Indirizzi:
Univ Utah, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 Anat, Salt Lake City, UT 84132 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 5, volume: 18, anno: 2001,
pagine: 458 - 472
SICI:
1044-7431(200111)18:5<458:NSCIXF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING DROSOPHILA EYE; LOOP-HELIX FACTORS; XENOPUS-EMBRYOS; CELL FATE; NERVOUS-SYSTEM; TRANSCRIPTION FACTORS; PRIMARY NEUROGENESIS; REPRESSOR PROTEINS; VERTEBRATE RETINA; MAMMALIAN HAIRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Vetter, ML Univ Utah, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 Lake City, UT 84132 USA
Citazione:
M.L. Schneider et al., "Notch signaling can inhibit Xath5 function in the neural plate and developing retina", MOL CELL NE, 18(5), 2001, pp. 458-472

Abstract

Neuronal differentiation Is regulated by both positive and negative regulatory factors; however, precisely how these factors interact to regulate retinogenesis Is still unclear. We have examined the ability of the Notch pathway to modulate the function of the basic helix-loop-helix factor Xath5. Overexpression of Xath5 by RNA injection into cleavage-stage blastomeres promotes ectopic neurogenesis at neural plate stages and ganglion cell differentiation in the developing retina. We found that these activities of Xath5 could be inhibited by coexpression of activated Notch. Notch inhibition of Xath5 function was reversed by coexpression with the zinc finger protein X-MyT1. The Notch effector enhancer-of-split related 1 (ESR1) also blocked Xath5 activity but efficient inhibition by ESR1 required the DNA binding basicdomain and the conserved WRPW motif. In addition, ESR1 inhibited the ability of Xath5 to directly activate the expression of XBrn3d, a transcription factor involved in retinal ganglion cell development. Xath5 could upregulate expression of X-Delta-1, ESR1, and ESR3, suggesting that Xath5 participates in a regulatory loop with the Notch pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:07:57