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Titolo:
Effect of cold acclimation on brown adipose tissue fatty acid synthesis inrats adapted to a high-protein, carbohydrate-free diet
Autore:
Moura, MAF; Kawashita, NH; Brito, SMRC; Brito, MN; Kettelhut, IC; Migliorini, RH;
Indirizzi:
Univ Sao Paulo, Sch Med, Dept Biochem, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCo Preto, SP, Brazil
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 12, volume: 50, anno: 2001,
pagine: 1493 - 1498
SICI:
0026-0495(200112)50:12<1493:EOCAOB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRUVATE-DEHYDROGENASE COMPLEX; SYMPATHETIC ACTIVATION; GLUCOSE-UTILIZATION; GLUCAGON-SECRETION; ACETYL-COENZYME; LIPID-SYNTHESIS; INSULIN; MUSCLE; INVIVO; NORADRENALINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Migliorini, RH Univ Sao Paulo, Sch Med, Dept Biochem, BR-14049900 RibeiraoPreto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCazil
Citazione:
M.A.F. Moura et al., "Effect of cold acclimation on brown adipose tissue fatty acid synthesis inrats adapted to a high-protein, carbohydrate-free diet", METABOLISM, 50(12), 2001, pp. 1493-1498

Abstract

The effect of cold acclimation on brown adipose tissue (BAT) fatty acid synthesis was investigated in rats adapted to a high-protein, carbohydrate-free diet. At an ambient temperature (25 degreesC), rates of fatty acid synthesis in BAT from rats adapted to the high-protein diet were reduced to 27% of rats fed the balanced diet and increased markedly after cold acclimation(10 days at 4 degreesC), although the increase was smaller than in controlrats. BAT weight increase induced by cold acclimation was smaller in rats fed the high-protein diet (30%) than in controls (100%). When expressed perwhole tissue, maximal activities of BAT glucose-6-phosphate dehydrogenase,malic enzyme, adenosine triphosphate (ATP)-citrate lyase, and acetyl-coenzyme A carboxylase were markedly reduced in high-protein diet-adapted rats at 25 degreesC and increased after cold acclimation in BAT from the 2 groups. However, when expressed per milligram protein, only acetyl-coenzyme A carboxylase showed an increase in both controls and in rats fed the high-protein diet. G6P-dehydrogenase, malic enzyme, and ATP-citrate lyase increased (per milligram protein) only in rats adapted to the high-protein diet and actually decreased in BAT from cold-acclimated control rats. Initial (before activation) pyruvate dehydrogenase (PDH) complex activity was lower in BAT from rats fed the high-protein diet at 25 degreesC and increased in cold-acclimated rats from the 2 groups. Circulating levels of insulin decreased inthe 2 groups after cold acclimation. The data suggest that the cold acclimation-induced increase in BAT lipogenesis in rats adapted to the high-protein diet was due to a restoration of sympathetic activity, which induced both BAT hyperplasia and activation of adipocyte free fatty acid (FFA) synthesis, with an important participation of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:54:11