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Titolo:
Role of excitatory amino acids in developmental epilepsies
Autore:
Raol, YH; Lynch, DR; Brooks-Kayal, AR;
Indirizzi:
Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Univ Penn, Childrens Hosp Philadelphia, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Neurol, Philadelphia, PA 19104 USA Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Pediat, Philadelphia, PA 19104 USA
Titolo Testata:
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
fascicolo: 4, volume: 7, anno: 2001,
pagine: 254 - 260
SICI:
1080-4013(2001)7:4<254:ROEAAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE-RECEPTOR; TEMPORAL-LOBE EPILEPSY; SUBUNIT MESSENGER-RNAS; LONG-TERM POTENTIATION; RAT-BRAIN; FUNCTIONAL-PROPERTIES; HIPPOCAMPAL-NEURONS; NMDA RECEPTORS; VISUAL-CORTEX; INDUCED EPILEPTOGENESIS;
Keywords:
epilepsy; development; glutamate; epileptogenesis; NMDA; AMPA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Brooks-Kayal, AR Childrens Hosp Philadelphia, Div Neurol, 502 Abramson ResCtr, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia 502 Abramson Res Ctr Philadelphia PA USA 19104
Citazione:
Y.H. Raol et al., "Role of excitatory amino acids in developmental epilepsies", MENT RET D, 7(4), 2001, pp. 254-260

Abstract

Altered excitatory amino acid (EAA) neurotransmission, mediated primarily by glutamate, is a major cause of the imbalance of excitation and inhibition which characterizes both early development and epileptogenesis. Glutamate's actions are mediated by three classes of receptors: NMDA, non-NMDA (AMPAand kainate), and metabotropic. Several features of normal EAA developmentcontribute to hyperexcitability in the immature brain, making it more prone to development of seizures. These features include increased density of NMDA receptors, differences in NMDA receptor subunit composition and activation kinetics, which result in reduced voltage-dependent Mg2+ blockade and longer receptor openings in early development. Also, the unique subunit composition of AMPA receptors present at synapses during early development results in increased Ca2+ influx. These and other differences in EAA signaling,in combination with developmental alterations in inhibitory neurotransmission, contribute to the increased seizure susceptibility seen in young animals and children. In turn, seizures themselves may alter EAA neurotransmission in an age-dependent manner. Age related changes in excitatory neurotransmission may, therefore, lead to differences in basic mechanisms of epileptogenesis between the immature arid mature brain, and may also alter the activity and efficacy of antiepileptic drugs in the pediatric age group. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:01:46