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Titolo:
Traumatic brain injury: Developmental differences in glutamate receptor response and the impact on treatment
Autore:
Lea, PM; Faden, AI;
Indirizzi:
Georgetown Univ, Ctr Med, Dept Neurosci, Washington, DC USA Georgetown Univ Washington DC USA Med, Dept Neurosci, Washington, DC USA Georgetown Univ, Ctr Med, Inst Cognit & Computat Sci, Washington, DC USA Georgetown Univ Washington DC USA nit & Computat Sci, Washington, DC USA Georgetown Univ, Ctr Med, Dept Pharmacol, Washington, DC USA Georgetown Univ Washington DC USA ed, Dept Pharmacol, Washington, DC USA
Titolo Testata:
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
fascicolo: 4, volume: 7, anno: 2001,
pagine: 235 - 248
SICI:
1080-4013(2001)7:4<235:TBIDDI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; CLOSED-HEAD-INJURY; EXCITOTOXIC NEURONAL DEATH; MESSENGER-RNA EXPRESSION; REGIONAL CEREBRAL EDEMA; RAT HIPPOCAMPAL SLICES; CENTRAL-NERVOUS-SYSTEM; PROTEIN-KINASE-C; EXCITATORY AMINO-ACIDS; SODIUM-CHANNEL BLOCKER;
Keywords:
glutamate receptors; apoptosis; necrosis; caspase; brain injury; development;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
223
Recensione:
Indirizzi per estratti:
Indirizzo: Faden, AI EP-04 Res Bldg,3970 Reservoir Rd NW, Washington, DC 20007 USA EP-04 Res Bldg,3970 Reservoir Rd NW Washington DC USA 20007 USA
Citazione:
P.M. Lea e A.I. Faden, "Traumatic brain injury: Developmental differences in glutamate receptor response and the impact on treatment", MENT RET D, 7(4), 2001, pp. 235-248

Abstract

Perinatal brain injury following trauma, hypoxia, and/or ischemia represents a substantial cause of pediatric disabilities including mental retardation. Such injuries lead to neuronal cell death through either necrosis or apoptosis. Numerous in vivo and in vitro studies implicate ionotropic (iGluRs) and metabotropic (mGluRs) glutamate receptors in the modulation of such cell death. Expression of glutamate receptors changes as a function of developmental age, with substantial implications for understanding mechanisms ofpost-injury cell death and its potential treatment. Recent findings suggest that the developing brain is more susceptible to apoptosis after injury and that such caspase mediated cell death may be exacerbated by treatment with N-methyl-D-aspartate receptor antagonists. Moreover, group 1 metabotropic glutamate receptors appear to have opposite effects on necrotic and apoptotic cell death. Understanding the relative roles of glutamate receptors inpost-traumatic or post-ischemic cell death as a function of developmental age may lead to novel targeted approaches to the treatment of pediatric brain injury. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:17:19