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Titolo:
FOSCARNET-GANCICLOVIR CYTOMEGALOVIRUS RETINITIS TRIAL .5. CLINICAL-FEATURES OF CYTOMEGALOVIRUS RETINITIS AT DIAGNOSIS
Autore:
LEWIS RA; CLOGSTON P; FAINSTEIN V; GROSS R; SAMO T; TUTTLE C; JABS DA; APUZZO L; BARTLETT J; COLESON L; DUNN JP; ELDRED L; FEINBERG J; FLYNN T; KING R; LESLIE J; BARRON B; GREENSPAN D; LECOUNT C; PEYMAN G; FRANKLIN R; HEINEMANN MH; POLSKY B; SQUIRES K; WISECAMPBELL S; FRIEDMAN AH; CHEUNG TW; JUSTIN N; TEICH S; SACKS H; SEVERIN C; FRIEDBERG DN; ADDESSI A; DIETERICH D; FROST K; WEINBERG D; JAMPOL L; MURPHY R; NAUGHTON K; HENDERLY D; HOLLAND GN; CHAFEY S; FALL H; HARDY WD; KIMBRELL C; MACARTHURCHANG L; FREEMAN WR; MEIXNERT L; PETERSON TJ; QUICENO JI; RICKMAN L; SIMANELLO MA; SPECTOR S; ODONNELL J; HOFFMAN L; IRVINE A; JACOBSON M; LARSON A; SEIFF S; WANNER M; DAVIS J; CHUANG E; ESPINAL M; MENDEZ P; VANDENBROUCKE R; CHEESEMAN SH; GITTINGER J; HAUBRICH R; KACHADOORIAN H; TOLSON K; KLINE JM; KLEMM AC; STEVENS M; WEBB R; BROWNBELLAMY J; MARKOWITZ JA; MEINERT CL; BROOKMEYER R; COLLINS KB; COLLISON BJ; DODGE J; DONITHAN M; FINK N; GERCZAK C; GILPIN AMK; HOLBROOK JT; ISAACSON MR; LEVINE CR; MARTIN B; MIN YI; MEINERT JL; OWENS RM; NOWAKOWSKI DJ; SAAH A; SINGER S; SMITH M; STERNBERG AL; TONASCIA J; VANNATTA ML; DAVIS MD; AGRESSEGAL M; ARMSTRONG J; BRICKBAUER J; BROTHERS R; CHOP M; FREITAG G; HUBBARD L; HURLBURT D; JENSEN K; KASTORFF L; KING B; MAGLI Y; MESSING S; MINER K; NEIDER M; STOPPENBACH V; THOMAS S; VANDERHOOFYOUNG M; STEWART G; HUGHES R; WELCH L; MOWERY R; ELLENBERG S; KORVICK J; CLARK T; SATTLER F; BROWN BW; CONWAY B; GRIZZLE J; NUSSENBLATT R; PHAIR J; SMITH H; WHITLEY R;
Indirizzi:
JOHNS HOPKINS CTR CLIN TRIALS,SOCA COORDINATING CTR,615 N WOLFE ST,STE 5010 BALTIMORE MD 21205 JOHNS HOPKINS CTR CLIN TRIALS,SOCA COORDINATING CTR BALTIMORE MD 21205 BAYLOR COLL MED,CULLEN EYE INST HOUSTON TX 77030 LOUISIANA STATE UNIV,MED CTR NEW ORLEANS LA 00000 MEM SLOAN KETTERING CANC CTR NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP NEW YORK NY 10021 MT SINAI SCH MED NEW YORK NY 00000 NYU,MED CTR NEW YORK NY 10016 NORTHWESTERN UNIV CHICAGO IL 60611 UNIV CALIF LOS ANGELES LOS ANGELES CA 00000 UNIV CALIF SAN DIEGO SAN DIEGO CA 92103 USN HOSP WASHINGTON DC 00000 UNIV CALIF SAN FRANCISCO SAN FRANCISCO CA 94143 UNIV MIAMI,SCH MED MIAMI FL 33152 UNIV MASSACHUSETTS,MED CTR WORCESTER MA 00000 JOHNS HOPKINS UNIV,SCH MED,CHAIRMANS OFF BALTIMORE MD 00000 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,COORDINATING CTR BALTIMORE MD 00000 UNIV WISCONSIN,FUNDUS PHOTOGRAPH READING CTR MADRID SPAIN ERC BIOSERV CORP,DRUG DISTRIBUT CTR ROCKVILLE MD 00000 NEI BETHESDA MD 20892 NIAID BETHESDA MD 20892
Titolo Testata:
American journal of ophthalmology
fascicolo: 2, volume: 124, anno: 1997,
pagine: 141 - 157
SICI:
0002-9394(1997)124:2<141:FCRT.C>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; VIRUS; AIDS; RETINOPATHY; MANIFESTATIONS; PROPHYLAXIS; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Lewis et al., "FOSCARNET-GANCICLOVIR CYTOMEGALOVIRUS RETINITIS TRIAL .5. CLINICAL-FEATURES OF CYTOMEGALOVIRUS RETINITIS AT DIAGNOSIS", American journal of ophthalmology, 124(2), 1997, pp. 141-157

Abstract

PURPOSE: To examine associations of systemic and ocular characteristics with severity of cytomegalovirus (CMV) retinitis at time of diagnosis and to compare ocular characteristics of eyes with and without CMV retinitis. METHODS: Eleven clinical centers, a data coordinating center, and a fundus photograph reading center participated in a randomized, controlled, multicenter clinical trial comparing foscarnet and ganciclovir as primary therapy for previously untreated CMV retinitis in 240 patients with AIDS. RESULTS: The systemic characteristics marginallyassociated with the percentage of retina affect ed by CMV in a patient's worse eye at diagnosis were chronic fever, weight loss, and numberof HIV-related illnesses. A positive CMV blood culture at diagnosis was similarly associated with bilateral disease. Laboratory measures ofdisease did not correlate well with measures of CMV retinitis severity. Many eyes with CMV retinitis had no or minimal lesion hemorrhage, but most had signs of inflammation. Patients often reported visual symptoms for involved eyes. The worse eyes (the eye with lesions covering the most retinal area) of patients with bilateral disease had greater retinal involvement, more lesions, and fewer degrees of visual field than did involved eyes of patients with unilateral disease. Visual symptoms, inflammation, indolent retinitis, and hemorrhagic lesions were associated with a greater percentage of retina affected by CMV. CONCLUSIONS: The findings support viremia as a mechanism of spread for untreated disease. Visual symptoms and signs of ocular inflammation were indicators both of the presence of CMV retinitis and of greater extent ofretinal area covered by CMV retinitis lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 03:24:37