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Titolo:
Hyperhomocysteinemia in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Autore:
Flemming, KD; Nguyen, TT; Abu-Lebdeh, HS; Parisi, JE; Wiebers, DO; Sicks, JRD; OFallon, WM; Petty, GW;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Cerebrovasc Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Div Endocrinol Metab Nutr & Internal Med, Rochester,MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 l Med, Rochester,MN 55905 USA Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 thol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Sect, Rochester, MN 55905 USA
Titolo Testata:
MAYO CLINIC PROCEEDINGS
fascicolo: 12, volume: 76, anno: 2001,
pagine: 1213 - 1218
SICI:
0025-6196(200112)76:12<1213:HIPWCA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCCLUSIVE ARTERIAL-DISEASE; INDEPENDENT RISK FACTOR; PLASMA HOMOCYSTEINE; VASCULAR-DISEASE; STROKE; DETERMINANTS; THERAPY; FAMILY; FOLATE; HOMOCYSTINURIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Petty, GW Mayo Clin & Mayo Fdn, Div Cerebrovasc Dis, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 5590505 USA
Citazione:
K.D. Flemming et al., "Hyperhomocysteinemia in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)", MAYO CLIN P, 76(12), 2001, pp. 1213-1218

Abstract

Objective: To determine whether patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) had evidence of increased homocysteine levels compared with non-CADASIL patients with ischemic stroke or transient ischemic attack. Patients and Methods: We compared fasting plasma homocysteine levels and levels 6 hours after oral loading with methionine, 100 mg/kg, in non-CADASILpatients with ischemic stroke or transient ischemic attack and in patientswith CADASIL. Prechallenge, postchallenge, and change in homocysteine levels between the 2 groups were compared with use of the Wilcoxon rank sum test. Results: CADASIL and non-CADASIL groups were similar in age (mean, 48.8 vs46.5 years, respectively; 2-tailed t test, P=.56) and sex (men, 86% vs 59%; Fisher exact test, P=.12). The 59 patients in the CADASIL group had higher median plasma homocysteine levels compared with the 14 patients in the non-CADASIL group, both in the fasting state (12.0 vs 9.0 mu mol/L; P=.03) and after methionine challenge (51.0 vs 34.0 mu mol/L; P=.007). Median difference between homocysteine levels before and after methionine challenge was greater in the CADASIL group than in the non-CADASIL group (34.5 vs 24.0 mumol/L; P=.02). Conclusion: Our findings raise the possibility that increased homocysteinelevels or abnormalities of homocysteine metabolism may have a role in the pathogenesis of CADASIL.

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Documento generato il 28/09/20 alle ore 02:39:13