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Titolo:
SPECIES-SPECIFIC B-CELL EPITOPE ON THE C-TERMINAL REGION OF THE ALPHA-ANTIGEN FROM MYCOBACTERIUM-SCROFULACEUM
Autore:
TAKANO M; OHARA N; NAITO M; MATSUMOTO S; MATSUO T; SHIRAI R; MIZUNO A; YAMADA T;
Indirizzi:
NAGASAKI UNIV,SCH DENT,1-7-1 SAKAMOTO NAGASAKI 852 JAPAN NAGASAKI UNIV,SCH DENT NAGASAKI 852 JAPAN NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 2 NAGASAKI 852 JAPAN
Titolo Testata:
Microbial pathogenesis
fascicolo: 2, volume: 23, anno: 1997,
pagine: 95 - 100
SICI:
0882-4010(1997)23:2<95:SBEOTC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVIS BCG; SECRETED ANTIGEN-85; CULTURE FILTRATE; CLONING; GENE; TUBERCULOSIS; ANTIBODIES; EXPRESSION; PROTEIN; COMPLEX;
Keywords:
MYCOBACTERIA; ALPHA ANTIGEN; SYNTHETIC PEPTIDES; B-CELL EPITOPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Takano et al., "SPECIES-SPECIFIC B-CELL EPITOPE ON THE C-TERMINAL REGION OF THE ALPHA-ANTIGEN FROM MYCOBACTERIUM-SCROFULACEUM", Microbial pathogenesis, 23(2), 1997, pp. 95-100

Abstract

In the amino acid (AA) sequences of alpha antigen from mycobacteria, C-terminal regions were variable among a variety of mycobacterial species though the N-terminal regions were relatively conserved. These regions may possess some species-specific antigenic determinants of the alpha antigen from Mycobacterium scrofulaceum (S-alpha). AAs288-300 of S-alpha fused to beta-galactosidase was reactive with the antisera raised against S-alpha. The same fused peptide did not react with the antisera raised against the alpha antigen from Mycobacterium avium (A-alpha) and Mycobacterium bovis BCG (B-alpha). B-cell epitope mapping thenwas performed focusing on the C-terminal region of S-alpha using the synthetic peptides. Their reactivities with antisera raised against the alpha antigens of three different mycobacterial species were assessed by ELISA. AAs279-286 were a cross-reactive common immunodominant region among three mycobacterial species. This region may be one of the crossreactive common epitopes in mycobacterial species. And AAs291-300 were reactive only with the antisera raised against S-alpha. This region may possess a species-specific epitope. (C) 1997 Academic Press Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:32:02