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Titolo:
Additional evidence for the anti-inflammatory and anti-allergic propertiesof the sesquiterpene polygodial
Autore:
da Cunha, FM; Frode, TS; Mendes, GL; Malheiros, A; Cechinel, V; Yunes, RA; Calixto, JB;
Indirizzi:
Univ Fed Santa Catarina, Ctr Biol Sci, Dept Pharmacol, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Florianopolis SC Brazil BR-88015420 BC SC, Brazil Univ Fed Santa Catarina, Dept Chem, BR-88049900 Florianopolis, SC, Brazil Univ Fed Santa Catarina Florianopolis SC Brazil BR-88049900 BC SC, Brazil
Titolo Testata:
LIFE SCIENCES
fascicolo: 2, volume: 70, anno: 2001,
pagine: 159 - 169
SICI:
0024-3205(20011130)70:2<159:AEFTAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED EAR EDEMA; TRACHEA IN-VITRO; DRYMIS-WINTERI; GUINEA-PIG; MANDEVILLA-VELUTINA; CAPSAICIN RECEPTOR; ARACHIDONIC-ACID; EXTRACT; MICE; MOUSE;
Keywords:
polygodial; paw oedema; pleurisy; inflammation; anaphylactic shock; mouse; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Calixto, JB Univ Fed Santa Catarina, Ctr Biol Sci, Dept Pharmacol, Rua Rerreira Lima 82, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Rua Rerreira Lima 82 Florianopolis SC Brazil BR-88015420 BC
Citazione:
F.M. da Cunha et al., "Additional evidence for the anti-inflammatory and anti-allergic propertiesof the sesquiterpene polygodial", LIFE SCI, 70(2), 2001, pp. 159-169

Abstract

This study evaluates further the anti-inflammatory and anti-allergic properties of polygodial, a sesquiterpene extracted from the barks plant Drymis winteri (Winteraceae). Polygodial (12.8 - 128.1 mu mol/kg, i.p.) 30 min prior, inhibited significantly the mouse paw oedema induced by prostaglandin E-2, bradykinin (BK) substance P (SP), dextran, platelet activating factor (PAF) or carrageenan. Polygodial also inhibited arachidonic acid-, capsaicin- and croton oil-induced ear oedema in mice. Polygodial (42.7 mu mol/kg, i.p), significantly inhibited both exudation and cell influx when assessed inthe pleurisy induced by SP and histamine, and to a less extent the inflammatory response caused by carrageenan, PAF, BK and des-Arg(9)-BK. Finally, polygodial (4.2 - 42.7 mu mol/kg, i.p.) produced dose-related inhibition of paw oedema induced by ovalbumin, protecting in a time-dependent manner the anaphylactic shock induced by endovenous administration of ovalbumin in animals which had been actively sensitised by this antigen. These and our previous results indicate that the major component present in the bark of the plant D. winteri, the sesquiterpene polygodial exerts an interesting antiinflammatory and anti-allergic properties when assessed in rats and mice. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:27:46