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Titolo:
Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells
Autore:
Jinn, TH; Kim, PD; Russell, PT; Church, CA; John, EO; Jung, TTK;
Indirizzi:
Loma Linda Univ, Sch Med, Dept Surg, Div Otolaryngol Head & Neck Surg, Loma Linda, CA 92350 USA Loma Linda Univ Loma Linda CA USA 92350 ck Surg, Loma Linda, CA 92350 USA Jerry L Pettis Mem Vet Adm Med Ctr, Loma Linda, CA USA Jerry L Pettis Mem Vet Adm Med Ctr Loma Linda CA USA Loma Linda, CA USA
Titolo Testata:
LARYNGOSCOPE
fascicolo: 12, volume: 111, anno: 2001,
pagine: 2105 - 2108
SICI:
0023-852X(200112)111:12<2105:DOOOCO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROUND WINDOW MEMBRANE; NEOMYCIN; PENETRATION; PERILYMPH;
Keywords:
ototoxicity; otic drops; Cipro HC; ciloxan; floxin; gentamicin; tobradex; acetasol HC; acetic acid; isolated outer hair cells; chinchilla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Jung, TTK 11790 Pecan Way, Loma Linda, CA 92354 USA 11790 Pecan Way Loma Linda CA USA 92354 oma Linda, CA 92354 USA
Citazione:
T.H. Jinn et al., "Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells", LARYNGOSCOP, 111(12), 2001, pp. 2105-2108

Abstract

Objectives. Otic drops are commonly used not only for otitis externa, but also for otorrhea in the presence of tympanostomy tubes or tympanic membrane perforations. Many studies have demonstrated the ototoxicity of common otic preparations such as Cortisporin (R) otic drops (Monarch Pharmaceuticals, Bristol, TN). The purpose of this study was to assess the relative ototoxicity of common otic preparations by direct exposure to isolated cochlear outer hair cells (OHCs). Methods: OHCs from adult chinchilla cochlea were exposed to standard bathing solution (control), acetic acid, Acetasol HC (R) (Alpharma USPD Inc., Baltimore, MD), Gentacidin (R) (CIBA Vision Ophthalmics, Atlanta, GA), and Tobradex (R) (Alcon, Fort Worth, TV. The cells were observed using an inverted microscope, and the images were recorded in digital still-frame and video, and analyzed on the Image Pro-Plus 3.0 program (Media Cybernetics, Silver Spring, MD). Results and Conclusions. As measured by time to cell death and change in morphology of OHCs, acetic acid with or without hydrocortisone was most toxic to OHCs. Cortisporin was more cytotoxic than gentamicin and Tobradex.

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Documento generato il 01/04/20 alle ore 02:04:19