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Titolo:
Essential roles for CD8(+) T cells and gamma interferon in protection of mice against retrovirus-induced immunosuppression
Autore:
Dittmer, U; Race, B; Peterson, KE; Stromnes, IM; Messer, RJ; Hasenkrug, KJ;
Indirizzi:
NIAID, Rocky Mt Lab, Persistent Viral Dis Lab, NIH, Hamilton, MT 59840 USANIAID Hamilton MT USA 59840 nt Viral Dis Lab, NIH, Hamilton, MT 59840 USA Univ Wurzburg, Inst Virol, Wurzburg, Germany Univ Wurzburg Wurzburg Germany Wurzburg, Inst Virol, Wurzburg, Germany
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 1, volume: 76, anno: 2002,
pagine: 450 - 454
SICI:
0022-538X(200201)76:1<450:ERFCTC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE LEUKEMIA-VIRUS; MONOCLONAL-ANTIBODIES; IN-VIVO; DENDRITIC CELLS; ERYTHROLEUKEMIA; AIDS; REQUIREMENTS; SUPPRESSION; ACTIVATION; RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Hasenkrug, KJ NIAID, Rocky Mt Lab, Persistent Viral Dis Lab, NIH, 903 S 4th St, Hamilton, MT 59840 USA NIAID 903 S 4th St Hamilton MT USA 59840 ilton, MT 59840 USA
Citazione:
U. Dittmer et al., "Essential roles for CD8(+) T cells and gamma interferon in protection of mice against retrovirus-induced immunosuppression", J VIROLOGY, 76(1), 2002, pp. 450-454

Abstract

It is known that both animal and human retroviruses typically cause immunosuppression in their respective hosts, but the mechanisms by which this occurs are poorly understood. The present study uses Friend virus (FV) infections of mice as a model to determine how major histocompatibility complex (MHC) genes influence immunosuppression. Previously, MHC-I genes were shown to influence antibody responses to potent antigenic challenges given during acute FY infection. The mapping of an immune response to an MHC-I gene implicated CD8(+) T cells in the mechanism, so we directly tested for their role by using in vivo CD8(+) T-cell depletions. Mice resistant to FV-induced immunosuppression became susceptible when they were depleted of CD8+ T cells. Resistance also required gamma interferon (IFN-gamma), as in vivo neutralization of IFN-gamma converted mice from a resistant to susceptible phenotype. On the other hand, susceptibility to FV-induced immunosuppression was dependent on the immunosuppressive cytokine, interleukin-10 (IL-10), as antibody responses were restored in susceptible mice when IL-10 function was blocked in vivo. Thus, FV-induced immunosuppression of antibody responses involves complex mechanisms controlled at least in part by CD8(+) T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:43:03