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Titolo:
The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines
Autore:
Higuchi, M; Kieff, E; Izumi, KM;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Channing Lab, Boston, MA 02115 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 robiol & Mol Genet, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 1, volume: 76, anno: 2002,
pagine: 455 - 459
SICI:
0022-538X(200201)76:1<455:TEVLMP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; TERMINAL CYTOPLASMIC DOMAIN; RECEPTOR-ASSOCIATED FACTORS; GROWTH TRANSFORMATION; JNK PATHWAY; C-TERMINUS; LMP1; MEMBRANE-PROTEIN-1; EXPRESSION; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Izumi, KM Univ Texas, Hlth Sci Ctr, Dept Microbiol, 7703 Floyd Curl Dr, San Antonio,TX 78229 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78229 78229 USA
Citazione:
M. Higuchi et al., "The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines", J VIROLOGY, 76(1), 2002, pp. 455-459

Abstract

Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1) has anintermediate domain between the two cytoplasmic carboxyl-terminal domains that are critical for transforming B-lymphocytes into lymphoblastoid cell lines (LCLs). The intermediate domain has been implicated in Janus kinase 3 (JAK3) association and activation. We now find that LCLs transformed by EBVrecombinants that express Flag-LMP1 with the putative JAK3 binding and activating intermediate domain deleted and LCLs transformed by Flag-LMP1 EBV recombinants have similar levels of phosphotyrosine-activated JAK3, signal transducer and activator of transcription 3 (STAT3), or STAT5 and similar very low levels of JAK3 associated with LMP1. Further, transient Flag-LMP1 expression in a B-lymphoma cell line transduces signals that upregulate TRAF1levels but does not alter JAK3 levels or activation state. Although these data indicate that the LMP1 putative JAK3 binding and activating intermediate domain does not mediate JAK3 association or activation in B-lymphocytes,JAK3 association with LMP1 could be significant, particularly in cells in which LMP1, JAK3, or a JAK3-associated protein is expressed at high levels.

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Documento generato il 03/06/20 alle ore 09:43:01