Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Complete sequence of a novel highly divergent simian T-cell lymphotropic virus from wild-caught red-capped mangabeys (Cercocebus torquatus) from Cameroon: A new primate T-lymphotropic virus type 3 subtype
Autore:
Meertens, L; Mahieux, R; Mauclere, P; Lewis, J; Gessain, A;
Indirizzi:
Inst Pasteur, Dept SIDA & Retrovirus, Unite Epidemiol & Physiopathol VirusOncogenes, F-75724 Paris 15, France Inst Pasteur Paris France 15 ol VirusOncogenes, F-75724 Paris 15, France Ctr Pasteur Cameroun, Yaounde, Cameroon Ctr Pasteur Cameroun Yaounde Cameroon steur Cameroun, Yaounde, Cameroon Int Zoo Vet Grp, Keigthley, W Yorkshire, England Int Zoo Vet Grp Keigthley W Yorkshire England hley, W Yorkshire, England
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 1, volume: 76, anno: 2002,
pagine: 259 - 268
SICI:
0022-538X(200201)76:1<259:CSOANH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLETE NUCLEOTIDE-SEQUENCE; LONG TERMINAL REPEAT; MOLECULAR CHARACTERIZATION; INTERSPECIES TRANSMISSION; PAN-PANISCUS; HTLV-II; LEUKEMIA; ORIGIN; TRANSCRIPTION; CHIMPANZEES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gessain, A Inst Pasteur, Dept SIDA & Retrovirus, Unite Epidemiol & Physiopathol VirusOncogenes, 25-28 Rue Dr Roux, F-75724 Paris 15, France Inst Pasteur 25-28 Rue Dr Roux Paris France 15 aris 15, France
Citazione:
L. Meertens et al., "Complete sequence of a novel highly divergent simian T-cell lymphotropic virus from wild-caught red-capped mangabeys (Cercocebus torquatus) from Cameroon: A new primate T-lymphotropic virus type 3 subtype", J VIROLOGY, 76(1), 2002, pp. 259-268

Abstract

Among 65 samples obtained from a primate rescue center located in Cameroon, two female adult red-capped mangabeys (Cercocebus torquatus) (CTO-602 andCTO-604), of wild-caught origin, had a peculiar human T-cell lymphotropic virus type 2 (HTLV-2)-like Western blot seroreactivity (p24, RGD21, +/-K55). Analyses of the simian T-cell lymphotropic virus type 3 (STLV-3)/CTO-604 complete proviral sequence (8,919 bp) indicated that this novel strain was highly divergent from HTLV-1 (60% nucleotide similarity), HTLV-2 (62%), or STLV-2 (62%) prototypes. It was, however, related to STLV-3/PH-969 (87%), adivergent STLV strain previously isolated from an Eritrean baboon. The STLV-3/CTO-604 sequence possesses the major open reading frames corresponding to the structural, enzymatic, and regulatory proteins. However, its long terminal repeat is shorter, with only two 21-bp repeats. Furthermore, as demonstrated by reverse transcriptase PCR, this new STLV exhibits significant differences from STLV-3/PH-969 at the mRNA splice junction position level. In all phylogenetic analyses, STLV-3/CTO-604 and STLV-3/PH-969 clustered in a highly supported single clade, indicating an evolutionary lineage independent from primate T-lymphotropic virus type 1 (PTLV-1) and PTLV-2. Nevertheless, the nucleotide divergence between STLV-3/PH-969 and STLV-3/CTO-604 isequivalent to or higher than the divergence observed between the differentHTLV-1 or HTLV-2 subtypes. Thus, the STLV-3/CTO-604 strain can be considered the prototype of a second subtype in the PTLV-3 type. The presence of two related viruses in evolutionarily distantly related African monkeys species, living in two opposite ecosystems (rain forest versus desert), reinforces the possible African origin of PTLV and opens new avenues regarding the search for a possible human counterpart of these viruses in individuals exhibiting such HTLV-2-like seroreactivities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:07:38