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Titolo:
Ion trap tandem mass spectrometry study of dexamethasone transformation products on light activated TiO2 surface
Autore:
Calza, P; Pelizzetti, E; Brussino, M; Baiocchi, C;
Indirizzi:
Univ Turin, Dipartimento Chim Analit, I-10125 Turin, Italy Univ Turin Turin Italy I-10125 timento Chim Analit, I-10125 Turin, Italy
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
fascicolo: 12, volume: 12, anno: 2001,
pagine: 1286 - 1295
SICI:
1044-0305(200112)12:12<1286:ITTMSS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AQUEOUS-SOLUTION; IN-VITRO; PHOTOCATALYTIC DEGRADATION; ORGANIC-MOLECULES; PULSE-RADIOLYSIS; TITANIUM-DIOXIDE; HUMAN LIVER; RADICALS; SUSPENSIONS; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Calza, P Univ Turin, Dipartimento Chim Analit, Via P Giuria 5, I-10125 Turin, Italy Univ Turin Via P Giuria 5 Turin Italy I-10125 10125 Turin, Italy
Citazione:
P. Calza et al., "Ion trap tandem mass spectrometry study of dexamethasone transformation products on light activated TiO2 surface", J AM SOC M, 12(12), 2001, pp. 1286-1295

Abstract

The photocatalytic transformation of dexamethasone and the formation of its intermediate compounds have been studied using titanium dioxide as a photocatalyst. The degradation of dexamethasone occurs easily through the formation of several hydroxy derivatives whose characterization has been made byHPLC/MS/MS. Even if both oxidative and reductive processes can be operating, only oxidative products have been identified in air saturated aqueous suspensions. A pattern of reaction pathways accounting for the observed intermediates is proposed. The obtained experimental evidence may be rationalized postulating the existence of a double initial mechanism. A single oxidation step resulting from the attack by one (OH)-O-. radical leading to the formation of five hydroxy-derivatives and a concomitant attack involving two (OH)-O-. radicals leading to the hydroxylation of the quinoid moiety of themolecule. (C) 2001 American Society for Mass Spectrometry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 17:15:35