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Titolo:
Expression of CD44 in synovium of rabbits with chronic arthritis induced by immunization with Escherichia coli
Autore:
Takagi, T; Okamoto, R; Sakai, N; Goto, H; Noyori, K; Koshino, T;
Indirizzi:
Yokohama City Univ, Sch Med, Dept Orthopaed Surg, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 12, volume: 28, anno: 2001,
pagine: 2579 - 2582
SICI:
0315-162X(200112)28:12<2579:EOCISO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERIAL LIPOPOLYSACCHARIDES; RHEUMATOID-ARTHRITIS; HYALURONATE; ANTIBODIES; ACTIVATION; INDUCTION; CYTOKINES; RECEPTOR; MICE;
Keywords:
Escherichia coli O : 14; rabbit; rheumatoid arthritis; CD44;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Takagi, T Yokohama City Univ, Sch Med, Dept Orthopaed Surg, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ 3-9 Fukuura Yokohama Kanagawa Japan 2360004 n
Citazione:
T. Takagi et al., "Expression of CD44 in synovium of rabbits with chronic arthritis induced by immunization with Escherichia coli", J RHEUMATOL, 28(12), 2001, pp. 2579-2582

Abstract

Objective. To investigate the expression of CD44 and its role in experimental chronic arthritis in rabbits. Methods. Rabbits were immunized with Escherichia coli O:14 for short (4 mo) and long (8-10 mo) periods. Immunohistochemical staining was performed onknees, using anti-CD44 antibodies. Results. Lymphocyte infiltration in the synovium was found in 30.0% of rabbits after short term immunization, and the rate increased to 58.3% after longterm immunization. CD44 was present in synovial lining cells in 30.0% ofrabbits after short term immunization, and it increased significantly (p <0.05) after longterm immunization (66.7%). CD44 was also observed in lymphocytes in knee synovium after longterm immunization (25.0%). Conclusion. CD44 in lining cells might play a role in promoting chronic arthritis in rabbits immunized with E. coli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:44:52