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Titolo:
Synaptic and morphological characteristics of temperature-sensitive and -insensitive rat hypothalamic neurones
Autore:
Griffin, JD; Saper, CB; Boulant, JA;
Indirizzi:
Ohio State Univ, Coll Med, Dept Physiol & Cell Biol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 & Cell Biol, Columbus, OH 43210 USA Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 l, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Program Neurosci, Boston, MA 02215 USA BethIsrael Deaconess Med Ctr Boston MA USA 02215 i, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 vard Univ, Sch Med, Boston, MA 02215 USA
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 2, volume: 537, anno: 2001,
pagine: 521 - 535
SICI:
0022-3751(200112)537:2<521:SAMCOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINOHYPOTHALAMIC TRACT NEURONS; CENTRAL-NERVOUS-SYSTEM; CERVICAL SPINAL-CORD; THERMOSENSITIVE NEURONS; ANTEROGRADE TRANSPORT; PARABRACHIAL NUCLEUS; SUPRAOPTIC NEURONS; PREOPTIC NEURONS; SOLITARY TRACT; SLICES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Boulant, JA Ohio State Univ, Coll Med, Dept Physiol & Cell Biol, 1645 NeilAve, Columbus, OH 43210 USA Ohio State Univ 1645 Neil Ave Columbus OH USA 43210 43210 USA
Citazione:
J.D. Griffin et al., "Synaptic and morphological characteristics of temperature-sensitive and -insensitive rat hypothalamic neurones", J PHYSL LON, 537(2), 2001, pp. 521-535

Abstract

1. Intracellular recordings were made from neurones in rat hypothalamic tissue slices, primarily in the preoptic area and anterior hypothalamus, a thermoregulatory region that integrates central and peripheral thermal information. The present study compared morphologies and local synaptic inputs ofwarm-sensitive and temperature-insensitive neurones.2. Warm-sensitive neurones oriented their dendrites perpendicular to the third ventricle, with medial dendrites directed toward the periventricular region and lateral dendrites directed toward the medial forebrain bundle. Incontrast, temperature-insensitive neurones generally oriented their dendrites parallel to the third ventricle.3. Both warm-sensitive and temperature-insensitive neurones displayed excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs). In most cases, EPSP and IPSP frequencies were not affected by temperature changes, suggesting that temperature-insensitive neurones are responsible for most local synapses within this hypothalamic network.4. Two additional neuronal groups were identified: silent neurones having no spontaneous firing rates and EPSP-driven neurones having action potentials that are primarily dependent on excitatory synaptic input from nearby neurones. Silent neurones had the most extensive dendritic trees, and these branched in all directions. In contrast, EPSP-driven neurones had the fewestdendrites, and usually the dendrites were oriented in only one direction (either medially or laterally), suggesting that these neurones receive more selective synaptic input.

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Documento generato il 30/11/20 alle ore 16:08:08