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Titolo:
Assessing plasma lipid levels, body weight, and hepatic and renal toxicityfollowing chronic oral administration of a water soluble phytostanol compound, FM-VP4, to gerbils.
Autore:
Wasan, KM; Najafi, S; Wong, J; Kwong, M; Pritchard, PH;
Indirizzi:
Univ British Columbia, Fac Pharmaceut Sci, Div Pharmaceut & Biopharmaceut,Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
fascicolo: 3, volume: 4, anno: 2001,
pagine: 228 - 234
SICI:
1482-1826(200109/12)4:3<228:APLLBW>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM-CHOLESTEROL; HYPERCHOLESTEROLEMIC SUBJECTS; LIPOPROTEIN CHOLESTEROL; ENRICHED MARGARINES; DIETARY-CHOLESTEROL; DEFICIENT MICE; PLANT STEROLS; SOY PROTEIN; PHYTOSTEROLS; SITOSTANOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Wasan, KM Univ British Columbia, Fac Pharmaceut Sci, Div Pharmaceut & Biopharmaceut,2146 E Mall Ave, Vancouver, BC V6T 1Z3, Canada Univ British Columbia 2146 E Mall Ave Vancouver BC Canada V6T 1Z3
Citazione:
K.M. Wasan et al., "Assessing plasma lipid levels, body weight, and hepatic and renal toxicityfollowing chronic oral administration of a water soluble phytostanol compound, FM-VP4, to gerbils.", J PHARM P S, 4(3), 2001, pp. 228-234

Abstract

The purpose of this project was to determine the effect of a FM-VP4 when incorporated into the diet or drinking water on plasma lipids, body weight, and hepatic and renal function following chronic oral administration to gerbils. Gerbils were administered water and food daily containing either no FM-VP4 (controls; n=6), 2% or 4% FM-VP4 incorporated into the gerbil diet (n=6 each treatment group) or 2% or 4% FM-VP4 dissolved in the drinking water(n=6 each treatment group). Body weight and food and water intake were monitored weekly. Following 8 weeks of this regiment blood was obtained via a cardiac puncture and all animals were sacrificed humanely. Plasma obtained from this blood was analyzed for total cholesterol, total triglyceride and high-density lipoprotein (HDL)-cholesterol levels by standard enzymatic andprecipitation techniques. Low-density lipoprotein (LDL)-cholesterol levelswere determined by the Friedewald equation. The plasma was also analyzed for changes in hepatic enzyme (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) and plasma creatinine (renal function) concentrations. 2% and 4% FM-VP4 administration incorporated both into the diet and in the drinking water resulted in a significant decrease in total plasma cholesterol and LDL cholesterol concentration compared to controls. Animals administered 4% FM-VP4 in either their diet or drinking water had significantlylower body weight following the 8 weeks of treatment compared to the othergroups. Significant differences in daily water intake was observed in all treatment groups with the exception of the 2% FM-VP4 in diet group comparedto controls. Significant differences in daily food intake were observed ingerbils administered 2% FM-VP4 in the drinking water and 4% FM-VP4 in the diet and drinking water groups compared to controls. A significant decreasein total plasma triglyceride concentration was observed in gerbils administered 4% FM-VP4 in their drinking water compared to controls. A significantincrease in HDL cholesterol concentrations was observed in gerbils administered 2% FM-VP4 in their diet and 4% FM-VP4 in their drinking water compared to controls. No significant elevations in AST, ALT and creatinine concentrations were reported for all treatment groups compared to controls. These findings suggest that FM-VP4 significantly decrease plasma lipids and body weight with no apparent hepatic or renal toxicity.

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Documento generato il 07/07/20 alle ore 05:10:07