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Titolo:
ERYTHROPOIETIN PRODUCTION IN HEALTHY-VOLUNTEERS SUBJECTED TO CONTROLLED HYPOBARIC HYPOXIA - FURTHER EVIDENCE AGAINST A ROLE FOR ADENOSINE
Autore:
GLEITER CH; BECKER T; WENZEL J;
Indirizzi:
UNIV GOTTINGEN,KLIN PHARMAKOL ABT,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY DLR,INST LUFT & RAUMFAHRTMED COLOGNE GERMANY
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 2, volume: 44, anno: 1997,
pagine: 203 - 205
SICI:
0306-5251(1997)44:2<203:EPIHST>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-TRANSPLANTATION; ERYTHROCYTOSIS; THEOPHYLLINE;
Keywords:
ERYTHROPOIETIN; THEOPHYLLINE; DIPYRIDAMOLE; HYPOBARIC HYPOXIA; PLASMA RENIN ACTIVITY; HEALTHY VOLUNTEERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Gleiter et al., "ERYTHROPOIETIN PRODUCTION IN HEALTHY-VOLUNTEERS SUBJECTED TO CONTROLLED HYPOBARIC HYPOXIA - FURTHER EVIDENCE AGAINST A ROLE FOR ADENOSINE", British journal of clinical pharmacology, 44(2), 1997, pp. 203-205

Abstract

Aims Objective of this study was to investigate whether adenosine modulates renal erythropoietin production. Methods In the present study erythropoietin production was stimulated by hypobaric hypoxia by subjecting healthy volunteers to a simulated altitude of 4000 m in a low pressure chamber for 5.5 h. During exposure to hypoxia the subjects received i.v. in a randomized, single-blind, cross-over fashion the non-specific adenosine antagonist theophylline, the adenosine reuptake inhibitor dipyridamole and placebo. Results Contrary to the working hypothesis, theophylline did not decrease and dipyridamole did not further boost erythropoietin concentrations. Conclusions The results are in agreement with our earlier study using haemorrhage as a controlled physiological stimulus of erythropoietin production, and would question a major role for adenosine as a mediator of renal erythropoietin production.

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Documento generato il 05/04/20 alle ore 07:07:20