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Titolo:
Treatment window for hypothermia in brain injury
Autore:
Markgraf, CG; Clifton, GL; Moody, MR;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Neurosurg, Houston, TX USA Univ Texas Houston TX USA Hlth Sci Ctr, Dept Neurosurg, Houston, TX USA Univ Texas, Hlth Sci Ctr, Vivian L Smith Fdn Neurol Res, Houston, TX USA Univ Texas Houston TX USA Vivian L Smith Fdn Neurol Res, Houston, TX USA
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 6, volume: 95, anno: 2001,
pagine: 979 - 983
SICI:
0022-3085(200112)95:6<979:TWFHIB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED CORTICAL IMPACT; SEVERE HEAD-INJURY; POSTTRAUMATIC HYPOTHERMIA; MODERATE HYPOTHERMIA; INTRACRANIAL HYPERTENSION; MILD HYPOTHERMIA; RAT; MODEL; GLUTAMATE; PRESSURE;
Keywords:
traumatic brain injury; impact injury; edema; hypothermia; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Markgraf, CG Schering Plough Corp, POB 32,144 Route 94, Lafayette, NJ 07848 USA Schering Plough Corp POB 32,144 Route 94 Lafayette NJ USA 07848
Citazione:
C.G. Markgraf et al., "Treatment window for hypothermia in brain injury", J NEUROSURG, 95(6), 2001, pp. 979-983

Abstract

Object. The goal of this study was to evaluate the therapeutic window for hypothermia treatment following experimental brain injury by measuring edema formation and functional outcome. Methods. Traumatic brain injury (TBI) was produced in anesthetized rats byusing cortical impact injury. Edema was measured in the ipsilateral and contralateral hemispheres by subtracting dry weight from wet weight, and neurological function was assessed using a battery of behavioral tests 24 hoursafter TBI In injured rats, it was found that brain water levels were elevated at I hour postinjury, compared with those in sham-injured control animals, and that edema peaked at 24 hours and remained elevated for 4 days. Hypothermia (3 hours at 30 degreesC) induced either immediately after TBI or 60 minutes after TBI significantly reduced early neurological deficits. Delay of treatment by 90 or 120 minutes postinjury did not result in this neurological protection. Immediate administration of hypothermia also significantly decreased the peak magnitude of edema at 24 hours and 48 hours postinjury, compared with that in normothermic injured control animals. When delayed by 90 minutes, hypothermia did not affect the pattern of edema formation. Conclusions. When hypothermia was administered immediately or 60 minutes after TBI, injured rats showed an improvement in functional outcome and a decrease in edema. Delayed hypothermia treatment had no effect on functional outcome or on edema.

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Documento generato il 25/11/20 alle ore 17:26:16