Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pyruvate carboxylation in neurons
Autore:
Hassel, B;
Indirizzi:
Norwegian Def Res Estab, N-2027 Kjeller, Norway Norwegian Def Res Estab Kjeller Norway N-2027 ab, N-2027 Kjeller, Norway
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 5, volume: 66, anno: 2001,
pagine: 755 - 762
SICI:
0360-4012(200112)66:5<755:PCIN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL METABOLIC COMPARTMENTATION; MITOCHONDRIAL MALIC ENZYME; RAT-BRAIN; C-13 NMR; PRIMARY CULTURES; IMMUNOCYTOCHEMICAL LOCALIZATION; AMINO-ACIDS; MONOCLONAL-ANTIBODIES; TRANSMITTER GLUTAMATE; ISOTOPOMER ANALYSIS;
Keywords:
anaplerosis; brain energy metabolism; glutamate; malic enzyme; neurotransmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Hassel, B Norwegian Def Res Estab, POB 25, N-2027 Kjeller, Norway Norwegian Def Res Estab POB 25 Kjeller Norway N-2027 er, Norway
Citazione:
B. Hassel, "Pyruvate carboxylation in neurons", J NEUROSC R, 66(5), 2001, pp. 755-762

Abstract

Carboxylation of pyruvate in the brain was for many years thought to occuronly in glia, an assumption that formed much of the basis for the concept of the glutamine cycle. It was shown recently, however, that carboxylation of pyruvate to malate occurs in neurons and that it supports formation of transmitter glutamate. The role of pyruvate carboxylation in neurons is to ensure tricarboxylic acid cycle activity by compensating for losses of alpha-ketoglutarate that occur through release of transmitter glutamate and GABA; these amino acids are a-ketoglutarate derivatives. Available data suggest that neuronal pyruvate carboxylation is quantitatively important. But because there is no net CO2 fixation in the brain, pyruvate carboxylation mustbe balanced by decarboxylation of malate or oxaloacetate. Such decarboxylation occurs in both neurons and astrocytes. Several in vitro studies have shown a neuroprotective effect of pyruvate supplementation. Pyruvate carboxylation may be one mechanism through which such treatment is effective, because pyruvate carboxylation through malic enzyme is active during energy deficiency and leads to an increase in the level of dicarboxylates that can bemetabolized through the tricarboxylic acid cycle for ATP production. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:49:47