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Titolo:
Kainic acid and seizure-induced Fos in subtypes of cerebrocortical neurons
Autore:
Hiscock, JJ; Mackenzie, L; Medvedev, A; Willoughby, JO;
Indirizzi:
Flinders Univ S Australia, Med Ctr, Dept Med, Adelaide, SA 5042, AustraliaFlinders Univ S Australia Adelaide SA Australia 5042 , SA 5042, Australia
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 6, volume: 66, anno: 2001,
pagine: 1094 - 1100
SICI:
0360-4012(200112)66:6<1094:KAASFI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LIMBIC SEIZURES; PICROTOXIN-INDUCED SEIZURES; CALCIUM-BINDING PROTEINS; RAT HIPPOCAMPUS; CEREBRAL-CORTEX; FRONTAL-CORTEX; EPILEPSY; BRAIN; NEOCORTEX; CELLS;
Keywords:
kainic acid; immunohistochemistry; calbindin D-28K; calretinin; parvalbumin; Fos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Hiscock, JJ Flinders Univ S Australia, Med Ctr, Dept Med, GPO Box 2100, Adelaide, SA 5042, Australia Flinders Univ S Australia GPO Box 2100 Adelaide SA Australia 5042
Citazione:
J.J. Hiscock et al., "Kainic acid and seizure-induced Fos in subtypes of cerebrocortical neurons", J NEUROSC R, 66(6), 2001, pp. 1094-1100

Abstract

Kainic acid injected in vivo into adult rats evokes the expression of the immediate early gene c-fos in the dentate gyrus and associated structures before a seizure occurs and in these and additional regions after a single motor seizure. The aim of this study was to identify cortical cell classes expressing Fos that correlate with these phenomena. Fos expression occurred before a seizure in the middle layers of entorhinal cortex in excitatory neurons and predominantly in calbindin D28-K-containing inhibitory neurons. Given the early Fos-labeling of these cells, we suggest they are associated with the hippocampal EEG events also seen at this stage of the effects of kainic acid, After a motor seizure Fos induction occurred in primary motor, sensory, piriform and entorhinal cortices, mainly in excitatory neurons, but also in a proportion of calcium binding protein-containing neurons proportionate to the degree of activation of the region as determined by Fos. Nearly 100% of neurons were Fos+ in entorhinal cortex, whereas 80% of excitatory and 50% of calcium binding protein-containing neurons were Fos+ in piriform cortex with lower proportions in neocortex. Of the calcium binding protein-containing neocortical neurons, calbindin D28-K cells exhibited the highest proportion of double labeling with Fos. This pattern of neocortical activation by kainic acid, a glutamate agonist, is only slightly different tothat seen after seizures caused by blockade of gamma aminobutyric acid receptors suggesting that seizures caused by different mechanisms utilize similar neo-cortical circuitry. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:34:35