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Titolo:
Neurogenesis of heterotopic gray matter in the brain of the microcephalic mouse
Autore:
Sun, XZ; Takahashi, S; Fukui, Y; Hisano, S; Kubota, Y; Sato, H; Inouye, M;
Indirizzi:
Natl Inst Radiol Sci, Res Grp 4, Chiba 2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 Res Grp 4, Chiba 2638555, Japan Univ Tokushima, Sch Med, Dept Anat, Tokushima 770, Japan Univ Tokushima Tokushima Japan 770 Med, Dept Anat, Tokushima 770, Japan Univ Tsukuba, Inst Basic Med Sci, Dept Anat, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 Anat, Tsukuba, Ibaraki 305, Japan Nagoya Univ, Dept Teratol & Genet, Div Mol & Cellular Adaptat, Nagoya, Aichi, Japan Nagoya Univ Nagoya Aichi Japan & Cellular Adaptat, Nagoya, Aichi, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 6, volume: 66, anno: 2001,
pagine: 1083 - 1093
SICI:
0360-4012(200112)66:6<1083:NOHGMI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIAL GLIAL-CELLS; CEREBRAL VENTRICULAR ZONE; FIBRILLARY ACIDIC PROTEIN; CALCIUM-BINDING PROTEINS; FETAL MONKEY NEOCORTEX; MONOCLONAL-ANTIBODY; NERVOUS-SYSTEM; GABAERGIC INTERNEURONS; IONIZING-RADIATION; GAMMA-IRRADIATION;
Keywords:
cerebral cortex; in utero; X-rays;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, XZ Natl Inst Radiol Sci, Res Grp 4, Chiba 2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 4, Chiba 2638555, Japan
Citazione:
X.Z. Sun et al., "Neurogenesis of heterotopic gray matter in the brain of the microcephalic mouse", J NEUROSC R, 66(6), 2001, pp. 1083-1093

Abstract

Neurogenesis of heterotopic gray matter in the brain of the microcephalic mouse prenatally exposed to X-rays at embryonic day 13 (E13) was studied immunohistochemically. Bromodeoxyuridine (BrdU) as a marker to label the migrating position of neuroblasts generated at various embryonic stages showed that no "inside-out" pattern of neuronal migration occurred in the heterotopic cell mass similar to that seen in the laminated cortex. Further resultsin which midkind (MK) immunoreactive radial glial fibers did not appear inthe heterotopic cell mass demonstrated that heterotopia formed in the absence of radial glia system. Different types of cells (pyramidal and non-pyramidal neurons) in the heterotopic cell mass were identified with immunoreactivity for anti-parvalbumin and anti-calbindin D-28K antibodies in additionto current histological methods. Two major types of neurons were mixed together with random distribution in the heterotopic cell mass. This finding indicates that irradiation might have no selective effects on the precursorsof pyramidal and non-pyramidal neurons. Moreover, anti-glial fibrillary acidic protein (GFAP) immunostaining showed that numerous astrocytes were present in the heterotopic cell mass. The fact that astrocytes appeared in theheterotopia without the transition from classic radial glial cells to astrocytes suggests that astrocytes might be generated directly from a separateastroglial precursor. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:02:18