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Titolo:
Protein trafficking mechanisms associated with neurite outgrowth and polarized sorting in neurons
Autore:
Tang, BL;
Indirizzi:
Natl Univ Singapore, Cent Imaging & Histol Facil, Singapore 117609, Singapore Natl Univ Singapore Singapore Singapore 117609 ngapore 117609, Singapore Natl Univ Singapore, NCA Lab, Inst Mol & Cell Biol, Singapore 117609, Singapore Natl Univ Singapore Singapore Singapore 117609 ngapore 117609, Singapore Natl Univ Singapore, Dept Biochem, Singapore 117609, Singapore Natl Univ Singapore Singapore Singapore 117609 ngapore 117609, Singapore
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 5, volume: 79, anno: 2001,
pagine: 923 - 930
SICI:
0022-3042(200112)79:5<923:PTMAWN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED HIPPOCAMPAL-NEURONS; NERVE GROWTH-FACTOR; PLASMA-MEMBRANE; EPITHELIAL-CELLS; AXON FORMATION; LIVING CELLS; PC12 CELLS; T-SNARE; TRANSPORT; COMPLEX;
Keywords:
exocyst complex; microtubule; motor protein; neurite outgrowth; Rab; SNARE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Tang, BL Natl Univ Singapore, Cent Imaging & Histol Facil, 30 Med Dr, Singapore 117609, Singapore Natl Univ Singapore 30 Med Dr Singapore Singapore 117609 ngapore
Citazione:
B.L. Tang, "Protein trafficking mechanisms associated with neurite outgrowth and polarized sorting in neurons", J NEUROCHEM, 79(5), 2001, pp. 923-930

Abstract

Neuronal differentiation in vitro and in vivo involves coordinated changesin the cellular cytoskeleton and protein trafficking processes. I review here recent progress in our understanding of the membrane trafficking aspects of neurite outgrowth of neurons in culture and selective microtubule-based polarized sorting in fully polarized neurons, focusing on the involvementof some key molecules. Early neurite outgrowth appears to involve the protein trafficking machineries that are responsible for constitutive trans-Golgi network (TGN) to plasma membrane exocytosis, utilizing transport carriergeneration mechanisms, SNARE proteins, Rab proteins and tethering mechanisms that are also found in non-neuronal cells. This vectorial TGN-plasma membrane traffic is directed towards several neurites, but can be switch to concentrate on the growth of a single axon. In a mature neuron, polarized targeting to the specific axonal and dendritic domains appears to involve selective microtubule-based mechanisms, utilizing motor proteins capable of distinguishing microtubule tracks to different destinations. The apparent gapsin our knowledge of these related protein transport processes will be highlighted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:49:35