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Titolo:
Clinical characteristics of neuroleptic-induced parkinsonism
Autore:
Hassin-Baer, S; Sirota, P; Korczyn, AD; Treves, TA; Epstein, B; Shabtai, H; Martin, T; Litvinjuk, Y; Giladi, N;
Indirizzi:
Tel Aviv Med Ctr & Sch Med, Dept Neurol, Movement Disorders Unit, IL-64239Tel Aviv, Israel Tel Aviv Med Ctr & Sch Med Tel Aviv Israel IL-64239 4239Tel Aviv, Israel Abarbanel Mental Hlth Ctr, Dept 6A, Bat Yam, Israel Abarbanel Mental Hlth Ctr Bat Yam Israel Ctr, Dept 6A, Bat Yam, Israel Tel Aviv Univ, Sieratzki Chair Neurol, Ramat Aviv, Israel Tel Aviv Univ Ramat Aviv Israel ratzki Chair Neurol, Ramat Aviv, Israel Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 11, volume: 108, anno: 2001,
pagine: 1299 - 1308
SICI:
0300-9564(2001)108:11<1299:CCONP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED PARKINSONISM; DISORDERS; THERAPY;
Keywords:
drug induced parkinsonism; neuroleptic induced parkinsonism; antipsychotics; extrapyramidal side effects; symmetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Giladi, N Tel Aviv Med Ctr & Sch Med, Dept Neurol, Movement Disorders Unit, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Med Ctr & Sch Med 6 Weizman St Tel Aviv Israel IL-64239
Citazione:
S. Hassin-Baer et al., "Clinical characteristics of neuroleptic-induced parkinsonism", J NEURAL TR, 108(11), 2001, pp. 1299-1308

Abstract

In order to characterize the clinical spectrum of neuroleptic-induced parkinsonism (NIP), we studied a population of consecutive psychiatric in-patients treated with neuroleptics for at least two weeks, who were diagnosed bytheir psychiatrist as having parkinsonism. Parkinsonism was confirmed by amovement disorders specialist who performed neurological assessment including the motor examination and the activities of daily living (ADL) sectionsof the Unified Parkinson's Disease Rating Scale (UPDRS), and the Hoehn andYahr (H&Y) staging. Seventy-five patients (54 males), aged 46 +/- 13 years (range 21 to 73 years) were included in the analysis. The mean duration of neuroleptic therapywas 15 +/- 12 years, while 61% were treated for more than 10 years. Most of the patients (n = 66, 88%) were scored as H&Y stage 2.5 or less. Rest tremor was present in 44% of the patients, and usually persisted in action. Forty-one patients (61%) had symmetrical involvement. Parkinsonian signs weresignificantly more common and pronounced in the upper in comparison with the lower limbs (p = 0.0001). Gait disturbances were mild and freezing of gait was very rare (n = 2). Neither age nor duration of therapy or their interaction affected the total motor score or any of the motor sub-scores. In conclusion, NIP differs from PD for more bilateral involvement with relativesymmetry, and by affecting upper limbs more often than the lower ones. NIPtends to be associated with the triad of bradykinesia, tremor and rigiditywhile PD tends to involve gait and posture more often. NIP develops unrelated to duration of neuroleptic treatment or age of the patient, suggesting an individual predisposition to blockage of the dopaminergic receptors.

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Documento generato il 17/09/19 alle ore 19:08:55