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Titolo:
Functional regional distribution of histamine receptors in the rat hippocampus: modulation of learning of an active avoidance response
Autore:
Alvarez, EO; Banzan, AM;
Indirizzi:
Univ Nacl Cuyo, Fac Ciencias Med, Inst Neurociencias & Humanidades Med, UNEFCO, RA-5500 Mendoza, Argentina Univ Nacl Cuyo Mendoza Argentina RA-5500FCO, RA-5500 Mendoza, Argentina
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 11, volume: 108, anno: 2001,
pagine: 1249 - 1261
SICI:
0300-9564(2001)108:11<1249:FRDOHR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTORHINAL CORTEX; WORKING-MEMORY; AREA CA1; ORGANIZATION; MECHANISMS; LESIONS; INVOLVEMENT; PROJECTIONS; H1-BLOCKERS; SUBICULUM;
Keywords:
histamine; hippocampus; avoidance response; learning; regional distribution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Alvarez, EO Univ Nacl Cuyo, Fac Ciencias Med, Inst Neurociencias & Humanidades Med, UNEFCO, CC Correo 33, RA-5500 Mendoza, Argentina Univ Nacl Cuyo CC Correo 33 Mendoza Argentina RA-5500 gentina
Citazione:
E.O. Alvarez e A.M. Banzan, "Functional regional distribution of histamine receptors in the rat hippocampus: modulation of learning of an active avoidance response", J NEURAL TR, 108(11), 2001, pp. 1249-1261

Abstract

The possible functional regional distribution of the histamine sensitive sites controlling the behavioral performance of learning of an active avoidance response in the hippocampal structure was studied. Adult male rats werestereotaxically implanted with microinjection cannula into three differentregions of the hippocampus: the ventral, the dorsal posterior and the dorsal anterior hippocampus. Different groups of rats were microinjected into these subregions with either saline, 9, 45 or 90 nmol of histamine. Five minlater all groups were subjected to learning of a conditioned response to an ultrasonic tone warning an electric shock to the feet of the animals. Three sessions of 8 trials were necessary in order to control animals learn the task. Results show that histamine microinjections into the ventral hippocampus were able to significantly inhibit the natural decrease of the latency to escape during trials, impairing the efficiency of learning. Histamine administration into the dorsal posterior hippocampus was slightly effectivein prolonging latency and impairing learning, while injections into the dorsal anterior region of the hippocampus had no effect. Results give a further support to the idea that histamine sensitive neurons in the ventral hippocampus are modulating the memory and learning mechanisms in the rat. In addition, evidence has been found suggesting a regional distribution of histamine sensitive neurons controlling learning of avoidance responses along the septo-temporal axis of the rat hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:31:38