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Titolo:
Hepatocyte transplantation: clinical and experimental application
Autore:
Ohashi, K; Park, F; Kay, MA;
Indirizzi:
Stanford Univ, Dept Pediat, Stanford, CA 94305 USA Stanford Univ StanfordCA USA 94305 , Dept Pediat, Stanford, CA 94305 USA Stanford Univ, Dept Genet, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 v, Dept Genet, Stanford, CA 94305 USA
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 11, volume: 79, anno: 2001,
pagine: 617 - 630
SICI:
0946-2716(200111)79:11<617:HTCAEA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LIVER-FAILURE; MEDIATED GENE-TRANSFER; IMMORTALIZED HUMAN HEPATOCYTES; HEPATITIS-B VIRUS; HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA; MICROCARRIER-ATTACHED HEPATOCYTES; TYROSINEMIA TYPE-I; LENTIVIRAL VECTOR; PRIMARY CULTURE; MOUSE HEPATOCYTES;
Keywords:
hepatocyte transplantation; gene therapy; hepatitis virus animal model; retrovirus vector; lentivirus vector;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Ohashi, K Stanford Univ, Dept Pediat, 300 Pasteur Dr, Stanford, CA 94305 USA Stanford Univ 300 Pasteur Dr Stanford CA USA 94305 CA 94305 USA
Citazione:
K. Ohashi et al., "Hepatocyte transplantation: clinical and experimental application", J MOL MED-J, 79(11), 2001, pp. 617-630

Abstract

Hepatocyte transplantation has been proposed as an alternative to whole-organ transplantation to support many forms of hepatic insufficiency. Based on a significant body of work, the technique of hepatocyte transplantation has recently moved into the clinic in order to reestablish liver function without organ transplantation or to bridge the time between whole-organ livertransplantation. In addition, hepatocyte transplantation has also been proposed as a liver-directed gene therapy for a number of inherited hepatic disorders by transplanting either freshly isolated hepatocytes or geneticallyaltered hepatocytes. To establish a research system based on the developing technology of hepatocyte transplantation, chimeric small animal models using human hepatocytes have recently been established, which would allow thestudy of human hepatocyte-specific functions, such as hepatitis viral infection and replication in vivo. Various aspects related to the recent progress and existing obstacles in the area of hepatocyte transplantation are summarized in this report.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:41:49