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Titolo:
Ascidian and amphioxus adh genes correlate functional and molecular features of the ADH family expansion during vertebrate evolution
Autore:
Canestro, C; Albalat, R; Hjelmqvist, L; Godoy, L; Jornvall, H; Gonzalez-Duarte, R;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 t Genet, E-08028 Barcelona, Spain Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 phys, S-17177 Stockholm, Sweden
Titolo Testata:
JOURNAL OF MOLECULAR EVOLUTION
fascicolo: 1, volume: 54, anno: 2002,
pagine: 81 - 89
SICI:
0022-2844(200201)54:1<81:AAAAGC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT FORMALDEHYDE DEHYDROGENASE; LIVER ALCOHOL-DEHYDROGENASE; RETINOIC ACID SYNTHESIS; CLASS-III; CLASS-I; GENOME DUPLICATION; DIVERGENCE; EXPRESSION; PROTEINS; ENZYME;
Keywords:
alcohol dehydrogenase; evolutionary rate; gene duplication; vertebrate genome evolution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Jornvall, H Univ Barcelona, Fac Biol, Dept Genet, Av Diagonal 645, E-08028Barcelona, Spain Univ Barcelona Av Diagonal 645 Barcelona Spain E-08028 Spain
Citazione:
C. Canestro et al., "Ascidian and amphioxus adh genes correlate functional and molecular features of the ADH family expansion during vertebrate evolution", J MOL EVOL, 54(1), 2002, pp. 81-89

Abstract

The alcohol dehydrogenase (ADH) family has evolved into at least eight ADHclasses during vertebrate evolution. We have characterized three prevertebrate forms of the parent enzyme of this family, including one from an urochordate (Ciona intestinalis) and two from cephalochordates (Branchiostoma floridae and Branchiostoma lanceolatum). An evolutionary analysis of the family was performed gathering data from protein and gene structures, exon-intron distribution, and functional features through chordate lines. Our data strongly support that the ADH family expansion occurred 500 million years ago, after the cephalochordate/vertebrate split, probably in the gnathostome subphylum line of the vertebrates. Evolutionary rates differ between the ancestral, ADH3 (glutathione-dependent formaldehyde dehydrogenase), and the emerging forms, including the classical alcohol dehydrogenase, ADH1, which has an evolutionary rate 3.6-fold that of the ADH3 form. Phylogenetic analysis and chromosomal mapping of the vertebrate Adh gene cluster suggest that family expansion took place by tandem duplications, probably concurrent with the extensive isoform burst observed before the fish/tetrapode split, rather than through the large-scale genome duplications also Postulated in early vertebrate evolution. The absence of multifunctionality in lower chordate ADHs and the structures compared argue in favor of the acquisition of newfunctions in vertebrate ADH classes. Finally, comparison between B. floridae and B. lanceolatum Adhs provides the first estimate for a cephalochordate speciation, 190 million years ago, probably concomitant with the beginning of the drifting of major land masses from the Pangea.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:16:58