Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pathogenicity of mumps virus in the marmoset
Autore:
Saika, S; Kidokoro, M; Ohkawa, T; Aoki, A; Suzuki, K;
Indirizzi:
Chiba Serum Inst, Chiba, Japan Chiba Serum Inst Chiba JapanChiba Serum Inst, Chiba, Japan
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 1, volume: 66, anno: 2002,
pagine: 115 - 122
SICI:
0146-6615(200201)66:1<115:POMVIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASEPTIC-MENINGITIS; RUBELLA VACCINE; NEUROVIRULENCE; MEASLES; STRAINS;
Keywords:
mumps virus; animal model; neurovirulence; marmoset;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Saika, S 2-6-1 Konodai Ichikawa, Chiba 2720827, Japan 2-6-1 Konodai Ichikawa Chiba Japan 2720827 Chiba 2720827, Japan
Citazione:
S. Saika et al., "Pathogenicity of mumps virus in the marmoset", J MED VIROL, 66(1), 2002, pp. 115-122

Abstract

The neurovirulence of two mumps virus strains was compared using marmosets. Marmosets were inoculated intravenously with the wild-type mumps virus Odate strain, resulting in evident meningitis in 1 of 3 marmosets at each of the weeks 3, 4, and 5 postinoculation, representing a total of 3 out of 9 marmosets. Nephritis, parotitis, pancreatitis, and tonsillitis were manifestin addition to central nervous system (CNS) sequelae. On the other hand, the Jeryl Lynn vaccine strain did not induce histopathological changes in the CNS and multiplication of the Jeryl Lynn strain was distinctly lower compared to that of the Odate strain in the marmoset. This is the first report to describe the induction of meningitis in non-human primates after peripheral inoculation of a wild-type mumps virus, presenting findings useful for the elucidation of the mechanism of infection and pathology of mumps virus in the CNS. The distinction observed between the Odate and Jeryl Lynn strains suggests the applicability of the marmoset model for the evaluation of any neurovirulence potential of vaccine strains. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:58:59