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Titolo:
Expression of cytokeratin 16 in human papillomavirus type 11-infected genital epithelium
Autore:
McClowry, TL; Shors, T; Brown, DR;
Indirizzi:
Indiana Univ, Sch Med, Div Infect Dis, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ct Dis, Indianapolis, IN 46202 USA Univ Wisconsin, Dept Biol & Microbiol, Oshkosh, WI 54901 USA Univ Wisconsin Oshkosh WI USA 54901 ol & Microbiol, Oshkosh, WI 54901 USA Indiana Univ, Sch Med, Dept Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 mmunol, Indianapolis, IN 46202 USA Richard L Roudebush Vet Adm Med Ctr, Indianapolis, IN 46202 USA Richard L Roudebush Vet Adm Med Ctr Indianapolis IN USA 46202 N 46202 USA
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 1, volume: 66, anno: 2002,
pagine: 96 - 101
SICI:
0146-6615(200201)66:1<96:EOC1IH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; CONDYLOMATA ACUMINATA; E5 PROTEIN; TRANSFORMATION; ACTIVATION; SKIN; HYPERPROLIFERATION; DIFFERENTIATION; KERATINIZATION; KERATINOCYTES;
Keywords:
cytokeratin 16; human papillomavirus type 11; genital epithelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, DR Indiana Univ, Sch Med, Div Infect Dis, Emerson Hall 435,545 Barnhill Dr, Indianapolis, IN 46202 USA Indiana Univ Emerson Hall 435,545 Barnhill Dr Indianapolis IN USA 46202
Citazione:
T.L. McClowry et al., "Expression of cytokeratin 16 in human papillomavirus type 11-infected genital epithelium", J MED VIROL, 66(1), 2002, pp. 96-101

Abstract

During normal keratinocyte differentiation, a coordinated expression of many cytoskeletal and regulatory proteins occurs. Several studies suggest that expression of some of these proteins is altered in epithelium infected bythe human papillomavirus (HPV). To examine protein expression, human foreskin tissue was infected with either the low-risk HPV type 11 or with HPV 83, a high-risk type. The foreskin tissue was implanted and grown in the athymic mouse xenograft system. Immunohistochemistry and immunoblot analysis ofhuman foreskin xenografts were performed to detect cytokeratin 16 (K16), aprotein previously identified in proliferative disorders of the skin. K16 was abundant in HPV 11-infected xenograft tissue, but was not detected in uninfected or HPV 83-infected tissue. Analysis of protein extracted from human biopsy tissue demonstrated the same expression patterns in natural infection by HPV 11. Reverse transcriptase PCR detected mRNA transcripts for K16in both experimental and natural HPV 11-infected tissues, but not in uninfected tissue. These studies suggest that K16 overexpression during HPV 11-infection is regulated at the level of transcription. The marked epithelial proliferation that occurs in HPV 11 infection may involve alterations in expression of cytoskeletal proteins, including K16. Determining the mechanisms of K16 transcriptional induction could lead to therapies with the abilityto reduce cell proliferation within infected tissue. (C) 2002 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 10:55:38