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Titolo:
Autoantibody appearance in cytomegalovirus-infected liver transplant recipients: Correlation with antigenemia
Autore:
Varani, S; Muratori, L; De Ruvo, N; Vivarelli, M; Lazzarotto, T; Gabrielli, L; Bianchi, FB; Bellusci, R; Landini, MP;
Indirizzi:
Univ Bologna, St Orsola Malpighi Gen Hosp, Dipartimento Discipline ChirurgRianimatorie & Tr, Bologna, Italy Univ Bologna Bologna Italy ine ChirurgRianimatorie & Tr, Bologna, Italy Univ Bologna, St Orsola Malpighi Gen Hosp, Dipartimento Med Interna, Bologna, Italy Univ Bologna Bologna Italy sp, Dipartimento Med Interna, Bologna, Italy Policlin S Orsola, Dipartimento Med Clin Specialist & Sperimentale, Sezione Microbiol, I-40138 Bologna, Italy Policlin S Orsola Bologna Italy I-40138 icrobiol, I-40138 Bologna, Italy
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 1, volume: 66, anno: 2002,
pagine: 56 - 62
SICI:
0146-6615(200201)66:1<56:AAICLT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIENDOTHELIAL CELL ANTIBODIES; ENDOTHELIAL-CELLS; POLYMORPHONUCLEAR LEUKOCYTES; ALLOGRAFT RECIPIENTS; CMV INFECTION; BONE-MARROW; AUTOIMMUNITY; VIRUSES; DISEASE; BLOOD;
Keywords:
autoimmunity; cytomegalovirus infection; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Landini, MP Policlin S Orsola, Dipartimento Med Clin Specialist & Sperimentale, Sezione Microbiol, Via Massarenti 9, I-40138 Bologna, Italy Policlin S Orsola Via Massarenti 9 Bologna Italy I-40138 taly
Citazione:
S. Varani et al., "Autoantibody appearance in cytomegalovirus-infected liver transplant recipients: Correlation with antigenemia", J MED VIROL, 66(1), 2002, pp. 56-62

Abstract

The presence of anti-endothelial cells (AECA), smooth muscle (SMA), antinuclear (ANA) and antimitochondrial (AMA) autoantibodies, and liver/kidney microsomal antibody type 1 (LKM1) was investigated retrospectively in sera ofliver transplant patients and correlated with cytomegalovirus (CMV) infection as determined by the antigenemia test and with the appearance of acute or chronic allograft rejection. Indirect immunofluorescence analysis was carried out in sequential sera from 40 liver transplant patients. Ten out of 23 antigenemia-positive and none of the antigenemia-negative patients developed serum autoantibodies (P = 0.002, Fisher's exact test). Anti-endothelial cell autoantibodies were found in nine cases and SMA in four patients. Antinuclear antibodies were detected in one otherwise autoantibody-negative patient. All but one case of autoantibody positivity were observed in the high antigenemia group (P < 0.0001, Fisher's exact test). In all but one case, autoantibodies were detected in blood during the antigenemia phase and inmost cases in coincidence with or after the antigenemia peak. Even though a statistically significant correlation was not found between autoantibody production and the development of acute or chronic allograft rejection, proportionally more acute rejection cases were observed in the autoantibody-positive than in the autoantibody-negative group. It has been speculated thatCMV-induced endothelial damage may be a potent antigenic stimulus, which leads to the production of anti-endothelial cells autoantibodies. Anti-endothelial cell autoantibodies may represent not only a marker of cell injury but also contribute to the progression of the inflammatory response leading to the exposure of tissue-privileged self antigens and the induction of other autoantibodies such as SMA. (C) 2002 Wiley-Liss, Inc.

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Documento generato il 05/04/20 alle ore 07:13:38